Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Risk factors for UK Plasmodium falciparum cases
AU - Pinsent, Amy
AU - Read, Jonathan M.
AU - Griffin, Jamie T.
AU - Smith, Valerie
AU - Gething, Peter W.
AU - Ghani, Azra C.
AU - Pasvol, Geoffrey
AU - Hollingsworth, T. Deirdre
PY - 2014/8/4
Y1 - 2014/8/4
N2 - Background: An increasing proportion of malaria cases diagnosed in UK residents with a history of travel to malaria endemic areas are due to Plasmodium falciparum.Methods: In order to identify travellers at most risk of acquiring malaria a proportional hazards model was used to estimate the risk of acquiring malaria stratified by purpose of travel and age whilst adjusting for entomological inoculation rate (EIR) and duration of stay in endemic countries.Results: Travellers visiting friends and relatives and business travellers were found to have significantly higher hazard of acquiring malaria (adjusted hazard ratio (HR) relative to that of holiday makers 7.4, 95% CI 6.4-8.5, p <0. 0001 and HR 3.4, 95% CI 2.9-3.8, p <0. 0001, respectively). All age-groups were at lower risk than children aged 0-15 years.Conclusions: These estimates of the increased risk for business travellers and those visiting friends and relatives should be used to inform programmes to improve awareness of the risks of malaria when travelling.
AB - Background: An increasing proportion of malaria cases diagnosed in UK residents with a history of travel to malaria endemic areas are due to Plasmodium falciparum.Methods: In order to identify travellers at most risk of acquiring malaria a proportional hazards model was used to estimate the risk of acquiring malaria stratified by purpose of travel and age whilst adjusting for entomological inoculation rate (EIR) and duration of stay in endemic countries.Results: Travellers visiting friends and relatives and business travellers were found to have significantly higher hazard of acquiring malaria (adjusted hazard ratio (HR) relative to that of holiday makers 7.4, 95% CI 6.4-8.5, p <0. 0001 and HR 3.4, 95% CI 2.9-3.8, p <0. 0001, respectively). All age-groups were at lower risk than children aged 0-15 years.Conclusions: These estimates of the increased risk for business travellers and those visiting friends and relatives should be used to inform programmes to improve awareness of the risks of malaria when travelling.
KW - Imported malaria
KW - Falciparum
KW - Travel
KW - MALARIA ENDEMIC COUNTRIES
KW - SUB-SAHARAN AFRICA
KW - IMPORTED MALARIA
KW - VISITING FRIENDS
KW - TRAVELERS
KW - CHILDREN
KW - SURVEILLANCE
KW - KNOWLEDGE
KW - TRANSMISSION
KW - PROPHYLAXIS
U2 - 10.1186/1475-2875-13-298
DO - 10.1186/1475-2875-13-298
M3 - Journal article
VL - 13
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
M1 - 298
ER -