TY - JOUR

T1 - Saccadic Eye Movements in Parkinson's Disease: II. Remembered Saccades— Towards a Unified Hypothesis?

AU - Lueck, C. J.

AU - Crawford, Trevor

AU - Henderson, L.

AU - Van Gisbergen, J. A. M.

AU - Duysens, J.

AU - Kennard, C.

PY - 1992

Y1 - 1992

N2 - Ten patients with mild to moderate Parkinson’s disease were compared withten age-matched normal controls in a series of saccadic paradigms in orderto test various hypotheses relating to the origin of the Parkinsonian saccadicdefect. The paradigms comprised a reflex saccade paradigm, a standardremembered saccade paradigm, a remembered saccade paradigm with delayedcentre-offset, and a remembered saccade paradigm with a second target flashimmediately prior to saccade execution. Finally, subjects executed both reflexand remembered saccades in a standard remembered paradigm (the “twosaccade”paradigm). As has been reported previously, Parkinsonian subjectsdemonstrated hypometria on all remembered saccade paradigms, particularlythe “two-saccade” paradigm. There was, however, no significant differencebetween the first three remembered saccade paradigms. These studies serveto refute a simple attentional capture hypothesis, and a hypothesis thatsuggests that the abnormality of remembered saccades is due to concurrent reflex saccade suppression. On the basis of the results, further hypothesesare advanced in an attempt to explain all published work on Parkinsoniansaccades.

AB - Ten patients with mild to moderate Parkinson’s disease were compared withten age-matched normal controls in a series of saccadic paradigms in orderto test various hypotheses relating to the origin of the Parkinsonian saccadicdefect. The paradigms comprised a reflex saccade paradigm, a standardremembered saccade paradigm, a remembered saccade paradigm with delayedcentre-offset, and a remembered saccade paradigm with a second target flashimmediately prior to saccade execution. Finally, subjects executed both reflexand remembered saccades in a standard remembered paradigm (the “twosaccade”paradigm). As has been reported previously, Parkinsonian subjectsdemonstrated hypometria on all remembered saccade paradigms, particularlythe “two-saccade” paradigm. There was, however, no significant differencebetween the first three remembered saccade paradigms. These studies serveto refute a simple attentional capture hypothesis, and a hypothesis thatsuggests that the abnormality of remembered saccades is due to concurrent reflex saccade suppression. On the basis of the results, further hypothesesare advanced in an attempt to explain all published work on Parkinsoniansaccades.

KW - Parkinson's disease

KW - Eye tracking

U2 - 10.1080/14640749208401325

DO - 10.1080/14640749208401325

M3 - Journal article

VL - 45

SP - 211

EP - 233

JO - Quarterly Journal of Experimental Psychology Series a Human Experimental Psychology

JF - Quarterly Journal of Experimental Psychology Series a Human Experimental Psychology

SN - 0272-4987

IS - 2

ER -