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    Rights statement: This is the author’s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, 87, 2017 DOI: 10.1016/j.europolymj.2016.10.022

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    Rights statement: This is the author’s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, ??, ?, 2016 DOI: 10.1016/j.europolymj.2016.10.022

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    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Sacrificial crystal templating of hyaluronic acid-based hydrogels

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Sacrificial crystal templating of hyaluronic acid-based hydrogels. / Thomas, Richelle; Chung, Paul; Modi, Shan P. et al.
In: European Polymer Journal, Vol. 87, 02.2017, p. 487-496.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Thomas, R, Chung, P, Modi, SP, Hardy, JG & Schmidt, CE 2017, 'Sacrificial crystal templating of hyaluronic acid-based hydrogels', European Polymer Journal, vol. 87, pp. 487-496. https://doi.org/10.1016/j.eurpolymj.2016.10.022

APA

Thomas, R., Chung, P., Modi, S. P., Hardy, J. G., & Schmidt, C. E. (2017). Sacrificial crystal templating of hyaluronic acid-based hydrogels. European Polymer Journal, 87, 487-496. https://doi.org/10.1016/j.eurpolymj.2016.10.022

Vancouver

Thomas R, Chung P, Modi SP, Hardy JG, Schmidt CE. Sacrificial crystal templating of hyaluronic acid-based hydrogels. European Polymer Journal. 2017 Feb;87:487-496. Epub 2016 Oct 14. doi: 10.1016/j.eurpolymj.2016.10.022

Author

Thomas, Richelle ; Chung, Paul ; Modi, Shan P. et al. / Sacrificial crystal templating of hyaluronic acid-based hydrogels. In: European Polymer Journal. 2017 ; Vol. 87. pp. 487-496.

Bibtex

@article{81280b1e38bd45c0bdb701e766d029aa,
title = "Sacrificial crystal templating of hyaluronic acid-based hydrogels",
abstract = "Natural tissues have intricate structures organized in a hierarchical fashion over multiple length scales ({\AA} to cm). These tissues commonly incorporate pores as a key feature that may regulate cell behavior. To enable the development of tissues scaffolds with biomimetic pore structures, it is important to investigate methods to impart pores to biomaterials, such as the use of novel sacrificial porogens. Here we report the use of sacrificial crystals to impart pores to biopolymer hydrogels (based on a methacrylated hyaluronic acid derivative) with macroscopic crystal templated pores embedded within them. The pore structure was investigated using microscopy (cryoSEM and confocal), and the specific sacrificial porogen used was found not only to impact the pore structure, but also swelling and mechanical properties. Such templated hydrogels have prospects for application as instructive tissue scaffolds (where the pore structure controls cell alignment, migration, etc.).",
keywords = "biomaterials, regenerative medicine, tissue scaffold, Hydrogel, MACROPORES",
author = "Richelle Thomas and Paul Chung and Modi, {Shan P.} and Hardy, {John George} and Schmidt, {Christine E}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, 87, 2017 DOI: 10.1016/j.europolymj.2016.10.022",
year = "2017",
month = feb,
doi = "10.1016/j.eurpolymj.2016.10.022",
language = "English",
volume = "87",
pages = "487--496",
journal = "European Polymer Journal",
issn = "0014-3057",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Sacrificial crystal templating of hyaluronic acid-based hydrogels

AU - Thomas, Richelle

AU - Chung, Paul

AU - Modi, Shan P.

AU - Hardy, John George

AU - Schmidt, Christine E

N1 - This is the author’s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, 87, 2017 DOI: 10.1016/j.europolymj.2016.10.022

PY - 2017/2

Y1 - 2017/2

N2 - Natural tissues have intricate structures organized in a hierarchical fashion over multiple length scales (Å to cm). These tissues commonly incorporate pores as a key feature that may regulate cell behavior. To enable the development of tissues scaffolds with biomimetic pore structures, it is important to investigate methods to impart pores to biomaterials, such as the use of novel sacrificial porogens. Here we report the use of sacrificial crystals to impart pores to biopolymer hydrogels (based on a methacrylated hyaluronic acid derivative) with macroscopic crystal templated pores embedded within them. The pore structure was investigated using microscopy (cryoSEM and confocal), and the specific sacrificial porogen used was found not only to impact the pore structure, but also swelling and mechanical properties. Such templated hydrogels have prospects for application as instructive tissue scaffolds (where the pore structure controls cell alignment, migration, etc.).

AB - Natural tissues have intricate structures organized in a hierarchical fashion over multiple length scales (Å to cm). These tissues commonly incorporate pores as a key feature that may regulate cell behavior. To enable the development of tissues scaffolds with biomimetic pore structures, it is important to investigate methods to impart pores to biomaterials, such as the use of novel sacrificial porogens. Here we report the use of sacrificial crystals to impart pores to biopolymer hydrogels (based on a methacrylated hyaluronic acid derivative) with macroscopic crystal templated pores embedded within them. The pore structure was investigated using microscopy (cryoSEM and confocal), and the specific sacrificial porogen used was found not only to impact the pore structure, but also swelling and mechanical properties. Such templated hydrogels have prospects for application as instructive tissue scaffolds (where the pore structure controls cell alignment, migration, etc.).

KW - biomaterials

KW - regenerative medicine

KW - tissue scaffold

KW - Hydrogel

KW - MACROPORES

U2 - 10.1016/j.eurpolymj.2016.10.022

DO - 10.1016/j.eurpolymj.2016.10.022

M3 - Journal article

VL - 87

SP - 487

EP - 496

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -