How could social scientists and cultural theorists take responsibility in engaging with science? How might they develop an experimental sensibility to the links between the production of knowledge and the production of existence or forms of life? Critically outlining key fields in the social and cultural studies of science, we interrogate a number of approaches to these questions. The first approach tries to make sense of how science operates in relation to economic, political and cultural forces. The second analyses science as a form of embodied work or practice. The third engages with science as collaborative-collective elaboration of events, ranging across cultural theory, contemporary art and participant ethnographies. This outline sketches a vector of responsibility across this diverse range of engagements, suggesting that contemporary movements between science and other knowledges constitute ethical and political imperatives.