The results of a search for squarks and gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a center-of-mass energy of √s=13 TeV are presented. The data set used was recorded during 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb−1. No significant excess beyond the expected background is found. Exclusion limits at 95% confidence level are set in a number of supersymmetric scenarios, reaching masses up to 2.1 TeV for gluino pair production and up to 1.25 TeV for squark pair production.