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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Cystic Fibrosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Cystic Fibrosis, 18,3, 2018 DOI: 10.1016/j.jcf.2018.10.006

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Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations

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Published
  • Tavs Qvist
  • Daniela K Schlüter
  • Vian Rajabzadeh
  • Peter John Diggle
  • Tania Pressler
  • Siobhan B Carr
  • David Taylor-Robinson
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<mark>Journal publication date</mark>1/05/2019
<mark>Journal</mark>Journal of Cystic Fibrosis
Issue number3
Volume18
Number of pages6
Pages (from-to)390-395
Publication StatusPublished
Early online date18/10/18
<mark>Original language</mark>English

Abstract

Background
Many risk factors for lung disease in cystic fibrosis (CF) display a seasonal pattern yet it is unclear whether this is reflected in seasonal fluctuations in lung function.
Methods
We conducted a longitudinal study using CF registries in Denmark and the UK. 485 individuals with a median of 103 FEV1 measurements per person and 7622 individuals with a median of nine FEV1 measures per person were included from Denmark and the UK respectively. We estimated the effect of seasonality on percent predicted FEV1 trajectories using mixed effects models whilst adjusting for clinically important covariates.
Results
We found no significant cyclical seasonal variation in lung function in either country. The maximum variation in percent predicted FEV1 around the yearly average was estimated to be 0.1 percentage points (95%CI 0 to 0.21) and 0.14 percentage points (95%CI 0 to 0.29) in Denmark and the UK, respectively. When considering possible step-like changes between the four seasons, we found that lung function was higher in spring compared to winter in the UK (0.34 percentage points, 95%CI 0.1 to 0.59) though the difference was not of clinical significance.
Conclusion
In both the UK and Denmark there may be small seasonal changes in lung function but this effect is not of clinical importance.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Journal of Cystic Fibrosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Cystic Fibrosis, 18,3, 2018 DOI: 10.1016/j.jcf.2018.10.006