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    Rights statement: This is the author’s version of a work that was accepted for publication in Epilepsy & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy & Behavior, 104, B, 2020 DOI: 10.1016/j.yebeh.2019.06.039

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Seizures in the context of occult cerebrovascular disease

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Seizures in the context of occult cerebrovascular disease. / Emsley, Hedley; Parkes, Laura M.
In: Epilepsy and Behavior, Vol. 104, No. B, 106396, 31.03.2020.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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APA

Emsley, H., & Parkes, L. M. (2020). Seizures in the context of occult cerebrovascular disease. Epilepsy and Behavior, 104(B), Article 106396. https://doi.org/10.1016/j.yebeh.2019.06.039

Vancouver

Emsley H, Parkes LM. Seizures in the context of occult cerebrovascular disease. Epilepsy and Behavior. 2020 Mar 31;104(B):106396. Epub 2019 Jul 29. doi: 10.1016/j.yebeh.2019.06.039

Author

Emsley, Hedley ; Parkes, Laura M. / Seizures in the context of occult cerebrovascular disease. In: Epilepsy and Behavior. 2020 ; Vol. 104, No. B.

Bibtex

@article{d2ac6ac5a0604291b555e23423ce4401,
title = "Seizures in the context of occult cerebrovascular disease",
abstract = "There is an important bidirectional relationship between seizures and cerebrovascular disease (CVD). Aside from poststroke epilepsy, Occult CVD is an important cause of late-onset seizures (LOS) and late-onset epilepsy (LOE). Late-onset seizures/LOE are associated with a threefold increased risk of subsequent clinical stroke. This relationship exists not only in later life, but with {\textquoteleft}late-onset{\textquoteright} seizures or epilepsy occurring from the fourth decade of life onwards. There is increasing evidence for the importance of hypertension and cerebral small vessel disease (SVD) in epileptogenesis, but there is a considerable need for further work to elucidate underlying mechanisms. There may be a disproportionately increased risk of intracerebral hemorrhage (ICH) after LOS/LOE; this too requires further study. There is also a bidirectional relationship between LOS/LOE and cognitive impairment/dementia: it is likely that there are important interactions between vascular and neurodegenerative pathological processes mediating LOE, stroke, and dementia. There is a pressing need for better epidemiological and natural history data as well as elucidation of epileptogenic mechanisms, in order to progress our understanding and to better inform clinical practice.",
keywords = "Late-onset seizures, late-onset epilepsy, cerebrovascular disease, small vessel disease, epileptogenesis",
author = "Hedley Emsley and Parkes, {Laura M.}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Epilepsy & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy & Behavior, 104, B, 2020 DOI: 10.1016/j.yebeh.2019.06.039 ",
year = "2020",
month = mar,
day = "31",
doi = "10.1016/j.yebeh.2019.06.039",
language = "English",
volume = "104",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "ELSEVIER ACADEMIC PRESS INC",
number = "B",

}

RIS

TY - JOUR

T1 - Seizures in the context of occult cerebrovascular disease

AU - Emsley, Hedley

AU - Parkes, Laura M.

N1 - This is the author’s version of a work that was accepted for publication in Epilepsy & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy & Behavior, 104, B, 2020 DOI: 10.1016/j.yebeh.2019.06.039

PY - 2020/3/31

Y1 - 2020/3/31

N2 - There is an important bidirectional relationship between seizures and cerebrovascular disease (CVD). Aside from poststroke epilepsy, Occult CVD is an important cause of late-onset seizures (LOS) and late-onset epilepsy (LOE). Late-onset seizures/LOE are associated with a threefold increased risk of subsequent clinical stroke. This relationship exists not only in later life, but with ‘late-onset’ seizures or epilepsy occurring from the fourth decade of life onwards. There is increasing evidence for the importance of hypertension and cerebral small vessel disease (SVD) in epileptogenesis, but there is a considerable need for further work to elucidate underlying mechanisms. There may be a disproportionately increased risk of intracerebral hemorrhage (ICH) after LOS/LOE; this too requires further study. There is also a bidirectional relationship between LOS/LOE and cognitive impairment/dementia: it is likely that there are important interactions between vascular and neurodegenerative pathological processes mediating LOE, stroke, and dementia. There is a pressing need for better epidemiological and natural history data as well as elucidation of epileptogenic mechanisms, in order to progress our understanding and to better inform clinical practice.

AB - There is an important bidirectional relationship between seizures and cerebrovascular disease (CVD). Aside from poststroke epilepsy, Occult CVD is an important cause of late-onset seizures (LOS) and late-onset epilepsy (LOE). Late-onset seizures/LOE are associated with a threefold increased risk of subsequent clinical stroke. This relationship exists not only in later life, but with ‘late-onset’ seizures or epilepsy occurring from the fourth decade of life onwards. There is increasing evidence for the importance of hypertension and cerebral small vessel disease (SVD) in epileptogenesis, but there is a considerable need for further work to elucidate underlying mechanisms. There may be a disproportionately increased risk of intracerebral hemorrhage (ICH) after LOS/LOE; this too requires further study. There is also a bidirectional relationship between LOS/LOE and cognitive impairment/dementia: it is likely that there are important interactions between vascular and neurodegenerative pathological processes mediating LOE, stroke, and dementia. There is a pressing need for better epidemiological and natural history data as well as elucidation of epileptogenic mechanisms, in order to progress our understanding and to better inform clinical practice.

KW - Late-onset seizures

KW - late-onset epilepsy

KW - cerebrovascular disease

KW - small vessel disease

KW - epileptogenesis

U2 - 10.1016/j.yebeh.2019.06.039

DO - 10.1016/j.yebeh.2019.06.039

M3 - Journal article

VL - 104

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - B

M1 - 106396

ER -