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Self-harm in bipolar disorder: findings from a prospective clinical database

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Self-harm in bipolar disorder : findings from a prospective clinical database. / Clements, Caroline; Jones, Steven; Morriss, Richard; Peters, Sarah; Cooper, Jayne; While, David; Kapur, Navneet.

In: Journal of Affective Disorders, Vol. 173, 01.03.2015, p. 113-119.

Research output: Contribution to journalJournal article

Harvard

Clements, C, Jones, S, Morriss, R, Peters, S, Cooper, J, While, D & Kapur, N 2015, 'Self-harm in bipolar disorder: findings from a prospective clinical database', Journal of Affective Disorders, vol. 173, pp. 113-119. https://doi.org/10.1016/j.jad.2014.10.012

APA

Clements, C., Jones, S., Morriss, R., Peters, S., Cooper, J., While, D., & Kapur, N. (2015). Self-harm in bipolar disorder: findings from a prospective clinical database. Journal of Affective Disorders, 173, 113-119. https://doi.org/10.1016/j.jad.2014.10.012

Vancouver

Clements C, Jones S, Morriss R, Peters S, Cooper J, While D et al. Self-harm in bipolar disorder: findings from a prospective clinical database. Journal of Affective Disorders. 2015 Mar 1;173:113-119. https://doi.org/10.1016/j.jad.2014.10.012

Author

Clements, Caroline ; Jones, Steven ; Morriss, Richard ; Peters, Sarah ; Cooper, Jayne ; While, David ; Kapur, Navneet. / Self-harm in bipolar disorder : findings from a prospective clinical database. In: Journal of Affective Disorders. 2015 ; Vol. 173. pp. 113-119.

Bibtex

@article{4fbf8dc1c75741f589cfaee66457f9fb,
title = "Self-harm in bipolar disorder: findings from a prospective clinical database",
abstract = "BACKGROUND: People with bipolar disorder may be at increased risk of suicidal behaviour but there are few prospective studies of self-harm in this group. Our aim was to describe the characteristics and outcome (in terms of repetition) for individuals with bipolar disorder who presented to hospital following self-harm.METHOD: A nested case-control study was carried out using a large prospective self-harm database (1997-2010) in Manchester, UK. Characteristics of bipolar cases and non-bipolar controls were compared using conditional logistic regression, and outcomes were assessed via survival analyses.RESULTS: Bipolar cases (n=103) were more likely to repeat self-harm than controls (n=515): proportion with at least one repeat episode 58% vs. 25%, HR 3.08 (95% CI; 2.2-4.18). Previous self-harm, unemployment, contact with psychiatric services and sleep disturbance were all more common in cases than controls. Even after adjustment for known risk factors, the risk of repetition remained higher in the bipolar group (adjusted HR 1.68; 95% CI; 1.10-2.56).LIMITATIONS: The study covers cases from hospital sites in Manchester, UK, and therefore only includes self-harm that was serious enough to present at hospital emergency departments.CONCLUSION: People with bipolar disorder who self-harm have a higher risk of repetition than people who self-harm more generally. Adjusting for some known risk factors moderated, but did not abolish, this finding. Other factors, such as impulsivity, may also be important.",
keywords = "Self-harm, Suicidal behaviour , Bipolar disorder",
author = "Caroline Clements and Steven Jones and Richard Morriss and Sarah Peters and Jayne Cooper and David While and Navneet Kapur",
year = "2015",
month = mar
day = "1",
doi = "10.1016/j.jad.2014.10.012",
language = "English",
volume = "173",
pages = "113--119",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Self-harm in bipolar disorder

T2 - findings from a prospective clinical database

AU - Clements, Caroline

AU - Jones, Steven

AU - Morriss, Richard

AU - Peters, Sarah

AU - Cooper, Jayne

AU - While, David

AU - Kapur, Navneet

PY - 2015/3/1

Y1 - 2015/3/1

N2 - BACKGROUND: People with bipolar disorder may be at increased risk of suicidal behaviour but there are few prospective studies of self-harm in this group. Our aim was to describe the characteristics and outcome (in terms of repetition) for individuals with bipolar disorder who presented to hospital following self-harm.METHOD: A nested case-control study was carried out using a large prospective self-harm database (1997-2010) in Manchester, UK. Characteristics of bipolar cases and non-bipolar controls were compared using conditional logistic regression, and outcomes were assessed via survival analyses.RESULTS: Bipolar cases (n=103) were more likely to repeat self-harm than controls (n=515): proportion with at least one repeat episode 58% vs. 25%, HR 3.08 (95% CI; 2.2-4.18). Previous self-harm, unemployment, contact with psychiatric services and sleep disturbance were all more common in cases than controls. Even after adjustment for known risk factors, the risk of repetition remained higher in the bipolar group (adjusted HR 1.68; 95% CI; 1.10-2.56).LIMITATIONS: The study covers cases from hospital sites in Manchester, UK, and therefore only includes self-harm that was serious enough to present at hospital emergency departments.CONCLUSION: People with bipolar disorder who self-harm have a higher risk of repetition than people who self-harm more generally. Adjusting for some known risk factors moderated, but did not abolish, this finding. Other factors, such as impulsivity, may also be important.

AB - BACKGROUND: People with bipolar disorder may be at increased risk of suicidal behaviour but there are few prospective studies of self-harm in this group. Our aim was to describe the characteristics and outcome (in terms of repetition) for individuals with bipolar disorder who presented to hospital following self-harm.METHOD: A nested case-control study was carried out using a large prospective self-harm database (1997-2010) in Manchester, UK. Characteristics of bipolar cases and non-bipolar controls were compared using conditional logistic regression, and outcomes were assessed via survival analyses.RESULTS: Bipolar cases (n=103) were more likely to repeat self-harm than controls (n=515): proportion with at least one repeat episode 58% vs. 25%, HR 3.08 (95% CI; 2.2-4.18). Previous self-harm, unemployment, contact with psychiatric services and sleep disturbance were all more common in cases than controls. Even after adjustment for known risk factors, the risk of repetition remained higher in the bipolar group (adjusted HR 1.68; 95% CI; 1.10-2.56).LIMITATIONS: The study covers cases from hospital sites in Manchester, UK, and therefore only includes self-harm that was serious enough to present at hospital emergency departments.CONCLUSION: People with bipolar disorder who self-harm have a higher risk of repetition than people who self-harm more generally. Adjusting for some known risk factors moderated, but did not abolish, this finding. Other factors, such as impulsivity, may also be important.

KW - Self-harm

KW - Suicidal behaviour

KW - Bipolar disorder

U2 - 10.1016/j.jad.2014.10.012

DO - 10.1016/j.jad.2014.10.012

M3 - Journal article

C2 - 25462404

VL - 173

SP - 113

EP - 119

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -