Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)

Chemistry

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re). / Coogan, Michael; Doyle, Robert P.; Valliant, John F. et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 57, No. 4, 04.2014, p. 255-261.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Coogan, M, Doyle, RP, Valliant, JF, Babich, JW & Zubieta, J 2014, 'Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 57, no. 4, pp. 255-261. https://doi.org/10.1002/jlcr.3164

APA

Coogan, M., Doyle, R. P., Valliant, J. F., Babich, J. W., & Zubieta, J. (2014). Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re). Journal of Labelled Compounds and Radiopharmaceuticals, 57(4), 255-261. https://doi.org/10.1002/jlcr.3164

Vancouver

Coogan M, Doyle RP, Valliant JF, Babich JW, Zubieta J. Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re). Journal of Labelled Compounds and Radiopharmaceuticals. 2014 Apr;57(4):255-261. doi: 10.1002/jlcr.3164

Author

Coogan, Michael ; Doyle, Robert P. ; Valliant, John F. et al. / Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re). In: Journal of Labelled Compounds and Radiopharmaceuticals. 2014 ; Vol. 57, No. 4. pp. 255-261.

Bibtex

@article{6b7c044a451d45b1a3e56fb091093044,

title = "Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)",

abstract = "Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3+ unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3+] derivative [BTBA-Re(CO)3]+ are discussed.",

keywords = "rhenium-tricarbonyl core , fluorescence spectroscopy , correlation of in vitro fluorescence and in vivo radioimaging , rhenium photophysics , bioconjugate chemistry",

author = "Michael Coogan and Doyle, {Robert P.} and Valliant, {John F.} and Babich, {John W.} and Jon Zubieta",

year = "2014",

month = apr,

doi = "10.1002/jlcr.3164",

language = "English",

volume = "57",

pages = "255--261",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "4",

}

RIS

TY - JOUR

T1 - Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)

AU - Coogan, Michael

AU - Doyle, Robert P.

AU - Valliant, John F.

AU - Babich, John W.

AU - Zubieta, Jon

PY - 2014/4

Y1 - 2014/4

N2 - Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3+ unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3+] derivative [BTBA-Re(CO)3]+ are discussed.

AB - Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3+ unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3+] derivative [BTBA-Re(CO)3]+ are discussed.

KW - rhenium-tricarbonyl core

KW - fluorescence spectroscopy

KW - correlation of in vitro fluorescence and in vivo radioimaging

KW - rhenium photophysics

KW - bioconjugate chemistry

U2 - 10.1002/jlcr.3164

DO - 10.1002/jlcr.3164

M3 - Journal article

VL - 57

SP - 255

EP - 261

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 4

ER -

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