TY - JOUR

T1 - Solubility behavior and thermodynamic modeling of inosine (form β) in four cosolvency systems at T = 278.15 to 323.15 K

AU - Shi, Yuli

AU - Zhang, Haojian

AU - Wang, Xiaodong

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical and Engineering Data, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acs.jced.0c00046

PY - 2020/4/9

Y1 - 2020/4/9

N2 - N,N-Dimethylformamide (DMF) as the main solvent with strong dissolving power was blended with four secondary solvents (ethanol, n-propanol, isopropanol, and propylene glycol) with relatively weak dissolving power to form many new solvents. The dispersion index (inosine (form β) mole fraction) in five organic solvents such as DMF and in the newly formed solvent was also obtained one by one with the static method commonly used in solid–liquid equilibrium. The temperature environment includes the high temperature set at 323.15 K, the low temperature set at 278.15 K, and an interval between each temperature of 5 K. The pressure environment was the atmospheric pressure in the natural state, and the usual value was 101.0 kPa. In a mixed system, temperature was a non-negligible influencing factor from beginning to end, and its increase often led the solute to the trend of high solubility. In addition, the proportion of the main solvent also dominated the solubilization trend of the inosine (form β); the larger the proportion of DMF, the easier the dissolution process. When both of the above factors were fixed at a certain point, the dispersing ability of the dispersing liquid composed of DMF and ethanol was undoubtedly the first. Three models (Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and modified Apelblat–Jouyban–Acree model) were used to correlate the solubility data. The largest relative average deviation and root-mean-square deviation values were 4.66 × 10–2 and 7.27 × 10–4, respectively. The dispersion data of inosine (form β) obtained through this experimental process and related thermodynamic parameters obtained through thermodynamic calculations have important application significance for its industrial production and further purification.

AB - N,N-Dimethylformamide (DMF) as the main solvent with strong dissolving power was blended with four secondary solvents (ethanol, n-propanol, isopropanol, and propylene glycol) with relatively weak dissolving power to form many new solvents. The dispersion index (inosine (form β) mole fraction) in five organic solvents such as DMF and in the newly formed solvent was also obtained one by one with the static method commonly used in solid–liquid equilibrium. The temperature environment includes the high temperature set at 323.15 K, the low temperature set at 278.15 K, and an interval between each temperature of 5 K. The pressure environment was the atmospheric pressure in the natural state, and the usual value was 101.0 kPa. In a mixed system, temperature was a non-negligible influencing factor from beginning to end, and its increase often led the solute to the trend of high solubility. In addition, the proportion of the main solvent also dominated the solubilization trend of the inosine (form β); the larger the proportion of DMF, the easier the dissolution process. When both of the above factors were fixed at a certain point, the dispersing ability of the dispersing liquid composed of DMF and ethanol was undoubtedly the first. Three models (Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and modified Apelblat–Jouyban–Acree model) were used to correlate the solubility data. The largest relative average deviation and root-mean-square deviation values were 4.66 × 10–2 and 7.27 × 10–4, respectively. The dispersion data of inosine (form β) obtained through this experimental process and related thermodynamic parameters obtained through thermodynamic calculations have important application significance for its industrial production and further purification.

U2 - 10.1021/acs.jced.0c00046

DO - 10.1021/acs.jced.0c00046

M3 - Journal article

VL - 65

SP - 2170

EP - 2177

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

SN - 0021-9568

IS - 4

ER -