In this work, aqueous 2‑amino‑1, 3‑propanediol solution (serinol) was investigated as a potential solvent for CO ₂ capture from different gas streams. Prior to CO ₂ solubility experiments, a qualitative prediction technique was performed on serinol to ensure its potentiality as a CO ₂ capture solvent. This was done using COSMO-RS approach based on quantum chemistry calculations. Based on this approach, serinol showed good affinity towards hydrogen–bond donors which proved to be beneficial in developing intermolecular interaction between serinol and CO ₂. The solubility of CO ₂ in serinol was then investigated at serinol concentrations ranging from 1 M to 3 M, temperatures ranging from 313.15 K to 353.15 K and CO ₂ partial pressures ranging from 1034.31 kPa to 2068.43 kPa. The solubility of CO ₂ in serinol reached a highest value of 1.64 mol of CO ₂/mol of serinol when the serinol concentration was 1 M, at 313.15 K and 2068.43 kPa. Meanwhile, Henry's law constant of CO ₂ in serinol was calculated using N ₂O analogy at 313.15 K and 333.15 K for molar concentrations of 1 M and 3 M of serinol. Results showed that the physical solubility of CO ₂ in serinol increased as the temperature and the concentration of the solution decreased. The lowest value of Henry's law constant of CO ₂ was 599.4 kPa·m ³·kmol ⁻¹, for 1 M of serinol at 313.15 K. Furthermore, the recyclability of 3 M of serinol was investigated at 313.15 K and partial pressures ranging from 1034.31 kPa to 2068.43 kPa. At 1034.31 kPa, the solubility of CO ₂ in 3 M of aqueous serinol after the 3rd regeneration cycles were reduced to 72.73%.