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    Rights statement: This is the author’s version of a work that was accepted for publication in Water Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Water Research, 130, 2018 DOI: 10.1016/j.watres.2017.11.068

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Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment

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Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment. / Casanovas-Massana, Arnau; Costa, Federico; Riediger, Irina N; Cunha, Marcelo; de Oliveira, Daiana; Mota, Diogenes C; Sousa, Erica; Querino, Vladimir A; Nery, Nivisson; Reis, Mitermayer G; Wunder, Elsio A; Diggle, Peter J; Ko, Albert I.

In: Water Research, Vol. 130, 01.03.2018, p. 176-184.

Research output: Contribution to journalJournal article

Harvard

Casanovas-Massana, A, Costa, F, Riediger, IN, Cunha, M, de Oliveira, D, Mota, DC, Sousa, E, Querino, VA, Nery, N, Reis, MG, Wunder, EA, Diggle, PJ & Ko, AI 2018, 'Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment' Water Research, vol. 130, pp. 176-184. DOI: 10.1016/j.watres.2017.11.068

APA

Casanovas-Massana, A., Costa, F., Riediger, I. N., Cunha, M., de Oliveira, D., Mota, D. C., ... Ko, A. I. (2018). Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment. DOI: 10.1016/j.watres.2017.11.068

Vancouver

Casanovas-Massana A, Costa F, Riediger IN, Cunha M, de Oliveira D, Mota DC et al. Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment. Water Research. 2018 Mar 1;130:176-184. Available from, DOI: 10.1016/j.watres.2017.11.068

Author

Casanovas-Massana, Arnau ; Costa, Federico ; Riediger, Irina N ; Cunha, Marcelo ; de Oliveira, Daiana ; Mota, Diogenes C ; Sousa, Erica ; Querino, Vladimir A ; Nery, Nivisson ; Reis, Mitermayer G ; Wunder, Elsio A ; Diggle, Peter J ; Ko, Albert I. / Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment. In: Water Research. 2018 ; Vol. 130. pp. 176-184

Bibtex

@article{5d943105a0a74499adacb7937e4b51d5,
title = "Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment",
abstract = "Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR). We used logistic and linear mixed models to identify factors that explained variation for the presence and concentration of Leptospira DNA. Among 335 sewage and 250 standing water samples, Leptospira DNA were detected in 36{\%} and 34{\%}, respectively. Among the 236 samples with positive results geometric mean Leptospira concentrations were 152 GEq/mL. The probability of finding Leptospira DNA was higher in sewage samples collected during the rainy season when increased leptospirosis incidence occurred, than during the dry season (47.2{\%} vs 12.5{\%}, respectively, p = 0.0002). There was a marked spatial and temporal heterogeneity in Leptospira DNA distribution, for which type of water, elevation, and time of day that samples were collected, in addition to season, were significant predictors. Together, these findings indicate that Leptospira are ubiquitous in the slum environment and that the water-related risk to which inhabitants are exposed is low. Seasonal increases in Leptospira presence may explain the timing of leptospirosis outbreaks. Effective prevention will need to consider the spatial and temporal dynamics of pathogenic Leptospira in surface waters to reduce the burden of the disease.",
keywords = "Leptospira, Leptospirosis, Surface water, Public health, Sewage, Urban slum",
author = "Arnau Casanovas-Massana and Federico Costa and Riediger, {Irina N} and Marcelo Cunha and {de Oliveira}, Daiana and Mota, {Diogenes C} and Erica Sousa and Querino, {Vladimir A} and Nivisson Nery and Reis, {Mitermayer G} and Wunder, {Elsio A} and Diggle, {Peter J} and Ko, {Albert I}",
note = "This is the author’s version of a work that was accepted for publication in Water Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Water Research, 130, 2018 DOI: 10.1016/j.watres.2017.11.068",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.watres.2017.11.068",
language = "English",
volume = "130",
pages = "176--184",
journal = "Water Research",
issn = "0043-1354",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment

AU - Casanovas-Massana,Arnau

AU - Costa,Federico

AU - Riediger,Irina N

AU - Cunha,Marcelo

AU - de Oliveira,Daiana

AU - Mota,Diogenes C

AU - Sousa,Erica

AU - Querino,Vladimir A

AU - Nery,Nivisson

AU - Reis,Mitermayer G

AU - Wunder,Elsio A

AU - Diggle,Peter J

AU - Ko,Albert I

N1 - This is the author’s version of a work that was accepted for publication in Water Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Water Research, 130, 2018 DOI: 10.1016/j.watres.2017.11.068

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR). We used logistic and linear mixed models to identify factors that explained variation for the presence and concentration of Leptospira DNA. Among 335 sewage and 250 standing water samples, Leptospira DNA were detected in 36% and 34%, respectively. Among the 236 samples with positive results geometric mean Leptospira concentrations were 152 GEq/mL. The probability of finding Leptospira DNA was higher in sewage samples collected during the rainy season when increased leptospirosis incidence occurred, than during the dry season (47.2% vs 12.5%, respectively, p = 0.0002). There was a marked spatial and temporal heterogeneity in Leptospira DNA distribution, for which type of water, elevation, and time of day that samples were collected, in addition to season, were significant predictors. Together, these findings indicate that Leptospira are ubiquitous in the slum environment and that the water-related risk to which inhabitants are exposed is low. Seasonal increases in Leptospira presence may explain the timing of leptospirosis outbreaks. Effective prevention will need to consider the spatial and temporal dynamics of pathogenic Leptospira in surface waters to reduce the burden of the disease.

AB - Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR). We used logistic and linear mixed models to identify factors that explained variation for the presence and concentration of Leptospira DNA. Among 335 sewage and 250 standing water samples, Leptospira DNA were detected in 36% and 34%, respectively. Among the 236 samples with positive results geometric mean Leptospira concentrations were 152 GEq/mL. The probability of finding Leptospira DNA was higher in sewage samples collected during the rainy season when increased leptospirosis incidence occurred, than during the dry season (47.2% vs 12.5%, respectively, p = 0.0002). There was a marked spatial and temporal heterogeneity in Leptospira DNA distribution, for which type of water, elevation, and time of day that samples were collected, in addition to season, were significant predictors. Together, these findings indicate that Leptospira are ubiquitous in the slum environment and that the water-related risk to which inhabitants are exposed is low. Seasonal increases in Leptospira presence may explain the timing of leptospirosis outbreaks. Effective prevention will need to consider the spatial and temporal dynamics of pathogenic Leptospira in surface waters to reduce the burden of the disease.

KW - Leptospira

KW - Leptospirosis

KW - Surface water

KW - Public health

KW - Sewage

KW - Urban slum

U2 - 10.1016/j.watres.2017.11.068

DO - 10.1016/j.watres.2017.11.068

M3 - Journal article

VL - 130

SP - 176

EP - 184

JO - Water Research

T2 - Water Research

JF - Water Research

SN - 0043-1354

ER -