For some time now, the field of Spatial Humanities has acknowledged the need for a system capable of the spatial exploration of historical and archaeological phenomena beyond Geographic Information Systems (GIS). This idea comes from the need to analyse holistically spatial information, including that which is not geographic (i.e. vague, symbolic and imaginary space). In addition, this need becomes more apparent when dealing with traditions that do not conform to the Modern/European/Cartesian conception of space in which GIS is rooted. This article, explores the use of Qualitative Spatial Representation (QSR) and Semantic Triples as possible alternative means to model complex and diverse expressions of spatial information, including social and symbolic conceptions in 16th century Mexican maps. Using as case study the map from the region of Atengo-Misquiahuala (Hidalgo) which combine the Mesoamerican and European traditions, we explore how these approaches might open new venues of research, potentially shedding light to long discussed and problematic Mesoamerican spatial categories. Focusing on a contained and partial example, we examine from a theoretical perspective and as a starting point, the possible future implementation of these approaches for historical and archaeological research.