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Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting

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Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting. / Alegana, Victor A.; Kigozi, Simon P.; Nankabirwa, Joaniter et al.
In: Parasites and Vectors, Vol. 9, 637, 12.12.2016.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Alegana, VA, Kigozi, SP, Nankabirwa, J, Arinaitwe, E, Kigozi, R, Mawejje, H, Kilama, M, Ruktanonchai, NW, Ruktanonchai, CW, Drakeley, C, Lindsay, SW, Greenhouse, B, Kamya, MR, Smith, DL, Atkinson, PM, Dorsey, G & Tatem, AJ 2016, 'Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting', Parasites and Vectors, vol. 9, 637. https://doi.org/10.1186/s13071-016-1917-3

APA

Alegana, V. A., Kigozi, S. P., Nankabirwa, J., Arinaitwe, E., Kigozi, R., Mawejje, H., Kilama, M., Ruktanonchai, N. W., Ruktanonchai, C. W., Drakeley, C., Lindsay, S. W., Greenhouse, B., Kamya, M. R., Smith, D. L., Atkinson, P. M., Dorsey, G., & Tatem, A. J. (2016). Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting. Parasites and Vectors, 9, Article 637. https://doi.org/10.1186/s13071-016-1917-3

Vancouver

Alegana VA, Kigozi SP, Nankabirwa J, Arinaitwe E, Kigozi R, Mawejje H et al. Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting. Parasites and Vectors. 2016 Dec 12;9:637. doi: 10.1186/s13071-016-1917-3

Author

Alegana, Victor A. ; Kigozi, Simon P. ; Nankabirwa, Joaniter et al. / Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting. In: Parasites and Vectors. 2016 ; Vol. 9.

Bibtex

@article{ecfc610ecdd843c596c0d7e12c6add8a,
title = "Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting",
abstract = "BackgroundAn increase in effective malaria control since 2000 has contributed to a decline in global malaria morbidity and mortality. Knowing when and how existing interventions could be combined to maximise their impact on malaria vectors can provide valuable information for national malaria control programs in different malaria endemic settings. Here, we assess the effect of indoor residual spraying on malaria vector densities in a high malaria endemic setting in eastern Uganda as part of a cohort study where the use of long-lasting insecticidal nets (LLINs) was high.MethodsAnopheles mosquitoes were sampled monthly using CDC light traps in 107 households selected randomly. Information on the use of malaria interventions in households was also gathered and recorded via a questionnaire. A Bayesian spatio-temporal model was then used to estimate mosquito densities adjusting for climatic and ecological variables and interventions.ResultsAnopheles gambiae (sensu lato) were most abundant (89.1%; n = 119,008) compared to An. funestus (sensu lato) (10.1%, n = 13,529). Modelling results suggest that the addition of indoor residual spraying (bendiocarb) in an area with high coverage of permethrin-impregnated LLINs (99%) was associated with a major decrease in mosquito vector densities. The impact on An. funestus (s.l.) (Rate Ratio 0.1508; 97.5% CI: 0.0144–0.8495) was twice as great as for An. gambiae (s.l.) (RR 0.5941; 97.5% CI: 0.1432–0.8577).ConclusionsHigh coverage of active ingredients on walls depressed vector populations in intense malaria transmission settings. Sustained use of combined interventions would have a long-term impact on mosquito densities, limiting infectious biting.",
keywords = "Anopheles, Anopheles gambiae, Indoor Residual Spraying , Malaria , Modelling",
author = "Alegana, {Victor A.} and Kigozi, {Simon P.} and Joaniter Nankabirwa and Emmanuel Arinaitwe and Ruth Kigozi and Henry Mawejje and Maxwell Kilama and Ruktanonchai, {Nick W.} and Ruktanonchai, {Corrine W.} and Chris Drakeley and Lindsay, {Steve W.} and Bryan Greenhouse and Kamya, {Moses R.} and Smith, {David L.} and Atkinson, {Peter Michael} and Grant Dorsey and Tatem, {Andrew J.}",
year = "2016",
month = dec,
day = "12",
doi = "10.1186/s13071-016-1917-3",
language = "English",
volume = "9",
journal = "Parasites and Vectors",
issn = "1756-3305",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting

AU - Alegana, Victor A.

AU - Kigozi, Simon P.

AU - Nankabirwa, Joaniter

AU - Arinaitwe, Emmanuel

AU - Kigozi, Ruth

AU - Mawejje, Henry

AU - Kilama, Maxwell

AU - Ruktanonchai, Nick W.

AU - Ruktanonchai, Corrine W.

AU - Drakeley, Chris

AU - Lindsay, Steve W.

AU - Greenhouse, Bryan

AU - Kamya, Moses R.

AU - Smith, David L.

AU - Atkinson, Peter Michael

AU - Dorsey, Grant

AU - Tatem, Andrew J.

PY - 2016/12/12

Y1 - 2016/12/12

N2 - BackgroundAn increase in effective malaria control since 2000 has contributed to a decline in global malaria morbidity and mortality. Knowing when and how existing interventions could be combined to maximise their impact on malaria vectors can provide valuable information for national malaria control programs in different malaria endemic settings. Here, we assess the effect of indoor residual spraying on malaria vector densities in a high malaria endemic setting in eastern Uganda as part of a cohort study where the use of long-lasting insecticidal nets (LLINs) was high.MethodsAnopheles mosquitoes were sampled monthly using CDC light traps in 107 households selected randomly. Information on the use of malaria interventions in households was also gathered and recorded via a questionnaire. A Bayesian spatio-temporal model was then used to estimate mosquito densities adjusting for climatic and ecological variables and interventions.ResultsAnopheles gambiae (sensu lato) were most abundant (89.1%; n = 119,008) compared to An. funestus (sensu lato) (10.1%, n = 13,529). Modelling results suggest that the addition of indoor residual spraying (bendiocarb) in an area with high coverage of permethrin-impregnated LLINs (99%) was associated with a major decrease in mosquito vector densities. The impact on An. funestus (s.l.) (Rate Ratio 0.1508; 97.5% CI: 0.0144–0.8495) was twice as great as for An. gambiae (s.l.) (RR 0.5941; 97.5% CI: 0.1432–0.8577).ConclusionsHigh coverage of active ingredients on walls depressed vector populations in intense malaria transmission settings. Sustained use of combined interventions would have a long-term impact on mosquito densities, limiting infectious biting.

AB - BackgroundAn increase in effective malaria control since 2000 has contributed to a decline in global malaria morbidity and mortality. Knowing when and how existing interventions could be combined to maximise their impact on malaria vectors can provide valuable information for national malaria control programs in different malaria endemic settings. Here, we assess the effect of indoor residual spraying on malaria vector densities in a high malaria endemic setting in eastern Uganda as part of a cohort study where the use of long-lasting insecticidal nets (LLINs) was high.MethodsAnopheles mosquitoes were sampled monthly using CDC light traps in 107 households selected randomly. Information on the use of malaria interventions in households was also gathered and recorded via a questionnaire. A Bayesian spatio-temporal model was then used to estimate mosquito densities adjusting for climatic and ecological variables and interventions.ResultsAnopheles gambiae (sensu lato) were most abundant (89.1%; n = 119,008) compared to An. funestus (sensu lato) (10.1%, n = 13,529). Modelling results suggest that the addition of indoor residual spraying (bendiocarb) in an area with high coverage of permethrin-impregnated LLINs (99%) was associated with a major decrease in mosquito vector densities. The impact on An. funestus (s.l.) (Rate Ratio 0.1508; 97.5% CI: 0.0144–0.8495) was twice as great as for An. gambiae (s.l.) (RR 0.5941; 97.5% CI: 0.1432–0.8577).ConclusionsHigh coverage of active ingredients on walls depressed vector populations in intense malaria transmission settings. Sustained use of combined interventions would have a long-term impact on mosquito densities, limiting infectious biting.

KW - Anopheles

KW - Anopheles gambiae

KW - Indoor Residual Spraying

KW - Malaria

KW - Modelling

U2 - 10.1186/s13071-016-1917-3

DO - 10.1186/s13071-016-1917-3

M3 - Journal article

VL - 9

JO - Parasites and Vectors

JF - Parasites and Vectors

SN - 1756-3305

M1 - 637

ER -