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Stability and coherence of biomarker identification methods in Fourier-transform infrared (FTIR) spectroscopy

Research output: Contribution to journalJournal article

Published

Journal publication date04/2014
JournalJournal of Biophotonics
Journal number3-4
Volume7
Number of pages12
Pages254-265
Original languageEnglish

Abstract

FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods. Validation of biomarker identification methods is difficult because, unlike classification, there is usually no reference biomarker against which to test the biomarkers extracted by a method. In
this paper, we propose a framework to assess and improve the stability of biomarkers derived by a method, and to compare biomarkers derived by different method set-ups and between different methods by means of a proposed “biomarkers similarity index”.