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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

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  • Hungyen Lin
  • Chunlei Pei
  • Daniel Markl
  • Yaochun Shen
  • James A. Elliott
  • J Axel Zeitler
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<mark>Journal publication date</mark>27/08/2018
<mark>Journal</mark>IET Microwaves, Antennas and Propagation
Issue number11
Volume12
Number of pages5
Pages (from-to)1775-1779
Publication StatusPublished
<mark>Original language</mark>English

Abstract

In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis. © The Institution of Engineering and Technology 2018.