To fabricate a virtual shape into the real world, the physical strength of the shape is an important consideration. We introduce a framework to consider both the strength and complexity of 3D frame structures. The key to the framework is a stress-oriented analysis and a semi-continuous condition in the shape representation that can both strengthen and simplify a structure at the same time. We formulate a novel semi-continuous optimization and present an elegant method to solve this optimization. We also extend our framework to general solid shapes by considering them as skeletal structures with non-uniform beams. We demonstrate our approach with applications such as topology simplification and structural strengthening.