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Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes

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Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes. / Al-Bachari, Sarah; Vidyasagar, Rishma; Emsley, Hedley C. A.; Parkes, Laura M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No. 10, 01.10.2017, p. 3409-3421.

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Al-Bachari, Sarah ; Vidyasagar, Rishma ; Emsley, Hedley C. A. ; Parkes, Laura M. / Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes. In: Journal of Cerebral Blood Flow and Metabolism. 2017 ; Vol. 37, No. 10. pp. 3409-3421.

Bibtex

@article{cb27df6ba07f4977978119a123a0c079,
title = "Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes",
abstract = "Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and six intermediates), 18 CP (mean age 70.1 ± 8.0 years) and 34 CN subjects (mean age 67.4 ± 7.6 years) completed a 3T MRI scan protocol including T2-weighted fluid-attenuated inversion recovery (FLAIR) and ASL. IPD patients showed diffuse regions of significantly prolonged AAT, small regions of lower CBF and greater WML burden by comparison with CN subjects. TD patients showed lower WML volume by comparison with PIGD patients. These imaging data thus show altered NVS in IPD, with some evidence for IPD phenotype-specific differences.",
keywords = "Magnetic resonance imaging, arterial spin labelling, cerebral blood flow, Parkinson’s disease, cerebrovascular disease",
author = "Sarah Al-Bachari and Rishma Vidyasagar and Emsley, {Hedley C. A.} and Parkes, {Laura M}",
note = "The final, definitive version of this article has been published in the Journal, Journal of Cerebral Blood Flow and Metabolism, 37 (10), 2017, {\circledC} SAGE Publications Ltd, 2017 by SAGE Publications Ltd at the Journal of Cerebral Blood Flow and Metabolism page: http://journals.sagepub.com/home/jcb on SAGE Journals Online: http://journals.sagepub.com/",
year = "2017",
month = "10",
day = "1",
doi = "10.1177/0271678X16688919",
language = "English",
volume = "37",
pages = "3409--3421",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Sage",
number = "10",

}

RIS

TY - JOUR

T1 - Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes

AU - Al-Bachari, Sarah

AU - Vidyasagar, Rishma

AU - Emsley, Hedley C. A.

AU - Parkes, Laura M

N1 - The final, definitive version of this article has been published in the Journal, Journal of Cerebral Blood Flow and Metabolism, 37 (10), 2017, © SAGE Publications Ltd, 2017 by SAGE Publications Ltd at the Journal of Cerebral Blood Flow and Metabolism page: http://journals.sagepub.com/home/jcb on SAGE Journals Online: http://journals.sagepub.com/

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and six intermediates), 18 CP (mean age 70.1 ± 8.0 years) and 34 CN subjects (mean age 67.4 ± 7.6 years) completed a 3T MRI scan protocol including T2-weighted fluid-attenuated inversion recovery (FLAIR) and ASL. IPD patients showed diffuse regions of significantly prolonged AAT, small regions of lower CBF and greater WML burden by comparison with CN subjects. TD patients showed lower WML volume by comparison with PIGD patients. These imaging data thus show altered NVS in IPD, with some evidence for IPD phenotype-specific differences.

AB - Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and six intermediates), 18 CP (mean age 70.1 ± 8.0 years) and 34 CN subjects (mean age 67.4 ± 7.6 years) completed a 3T MRI scan protocol including T2-weighted fluid-attenuated inversion recovery (FLAIR) and ASL. IPD patients showed diffuse regions of significantly prolonged AAT, small regions of lower CBF and greater WML burden by comparison with CN subjects. TD patients showed lower WML volume by comparison with PIGD patients. These imaging data thus show altered NVS in IPD, with some evidence for IPD phenotype-specific differences.

KW - Magnetic resonance imaging

KW - arterial spin labelling

KW - cerebral blood flow

KW - Parkinson’s disease

KW - cerebrovascular disease

U2 - 10.1177/0271678X16688919

DO - 10.1177/0271678X16688919

M3 - Journal article

VL - 37

SP - 3409

EP - 3421

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 10

ER -