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Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)

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  • S. Vasudevan
  • J. A. Smith
  • M. Wojdyla
  • A. DiTrapani
  • P. E. Kruger
  • T. McCabe
  • N. C. Fletcher
  • S. J. Quinn
  • J. M. Kelly
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<mark>Journal publication date</mark>2010
<mark>Journal</mark>Dalton Transactions
Issue number48
Volume39
Number of pages1
Pages (from-to)11687-11687
Publication statusPublished
Original languageEnglish

Abstract

[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.