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Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)

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Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010). / Vasudevan, S.; Smith, J. A.; Wojdyla, M. et al.
In: Dalton Transactions, Vol. 39, No. 48, 2010, p. 11687-11687.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Vasudevan, S, Smith, JA, Wojdyla, M, DiTrapani, A, Kruger, PE, McCabe, T, Fletcher, NC, Quinn, SJ & Kelly, JM 2010, 'Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)', Dalton Transactions, vol. 39, no. 48, pp. 11687-11687. https://doi.org/10.1039/C0DT90099K

APA

Vasudevan, S., Smith, J. A., Wojdyla, M., DiTrapani, A., Kruger, P. E., McCabe, T., Fletcher, N. C., Quinn, S. J., & Kelly, J. M. (2010). Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010). Dalton Transactions, 39(48), 11687-11687. https://doi.org/10.1039/C0DT90099K

Vancouver

Vasudevan S, Smith JA, Wojdyla M, DiTrapani A, Kruger PE, McCabe T et al. Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010). Dalton Transactions. 2010;39(48):11687-11687. doi: 10.1039/C0DT90099K

Author

Vasudevan, S. ; Smith, J. A. ; Wojdyla, M. et al. / Substituted dipyridophenazine complexes of Cr(III) : synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010). In: Dalton Transactions. 2010 ; Vol. 39, No. 48. pp. 11687-11687.

Bibtex

@article{af9b5cb042014ef5bc0c6de96c46949e,
title = "Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)",
abstract = "[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.",
author = "S. Vasudevan and Smith, {J. A.} and M. Wojdyla and A. DiTrapani and Kruger, {P. E.} and T. McCabe and Fletcher, {N. C.} and Quinn, {S. J.} and Kelly, {J. M.}",
year = "2010",
doi = "10.1039/C0DT90099K",
language = "English",
volume = "39",
pages = "11687--11687",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "48",

}

RIS

TY - JOUR

T1 - Substituted dipyridophenazine complexes of Cr(III)

T2 - synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)

AU - Vasudevan, S.

AU - Smith, J. A.

AU - Wojdyla, M.

AU - DiTrapani, A.

AU - Kruger, P. E.

AU - McCabe, T.

AU - Fletcher, N. C.

AU - Quinn, S. J.

AU - Kelly, J. M.

PY - 2010

Y1 - 2010

N2 - [Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.

AB - [Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.

U2 - 10.1039/C0DT90099K

DO - 10.1039/C0DT90099K

M3 - Journal article

VL - 39

SP - 11687

EP - 11687

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 48

ER -