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Swimming with protists : perception, motility and flagellum assembly.

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<mark>Journal publication date</mark>11/2008
<mark>Journal</mark>Nature Reviews in Microbiology
Issue number11
Volume6
Number of pages13
Pages (from-to)838-850
Publication statusPublished
Original languageEnglish

Abstract

In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence.