Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis and characterisation of enhanced barrier polyurethane for encapsulation of implantable medical devices
AU - Roohpour, N.
AU - Wasikiewicz, J.M.
AU - Paul, D.
AU - Vadgama, P.
AU - Rehman, I.U.
PY - 2009
Y1 - 2009
N2 - Polymeric membranes have been used as interfaces between implantable devices and biological tissues to operate as a protective barrier from water exchanging and to enhance biocompatibility. Polyurethanes have been used as biocompatible membranes for decades. In this study, copolymers of polyether urethane (PEU) with polydimethylsiloxane (PDMS) were synthesised with the goal of creating materials with low water permeability and high elasticity. PDMS was incorporated into polymer backbone as a part of the soft segment during polyurethane synthesis and physical properties as well as water permeability of resulting copolymer were studied in regard to PDMS content. Increase in PDMS content led to increase of microphase separation of the copolymer and corresponding increase in elastic modulus. Surface energy of the polymer was decreased by incorporating PDMS compared to unmodified PEU. PDMS in copolymer formed a hydrophobic surface which caused reduction in water permeability and water uptake of the membranes. Thus, PDMS containing polyurethane with its potent water resistant properties demonstrated a great promise for use as an implantable encapsulation material. © 2009 Springer Science+Business Media, LLC.
AB - Polymeric membranes have been used as interfaces between implantable devices and biological tissues to operate as a protective barrier from water exchanging and to enhance biocompatibility. Polyurethanes have been used as biocompatible membranes for decades. In this study, copolymers of polyether urethane (PEU) with polydimethylsiloxane (PDMS) were synthesised with the goal of creating materials with low water permeability and high elasticity. PDMS was incorporated into polymer backbone as a part of the soft segment during polyurethane synthesis and physical properties as well as water permeability of resulting copolymer were studied in regard to PDMS content. Increase in PDMS content led to increase of microphase separation of the copolymer and corresponding increase in elastic modulus. Surface energy of the polymer was decreased by incorporating PDMS compared to unmodified PEU. PDMS in copolymer formed a hydrophobic surface which caused reduction in water permeability and water uptake of the membranes. Thus, PDMS containing polyurethane with its potent water resistant properties demonstrated a great promise for use as an implantable encapsulation material. © 2009 Springer Science+Business Media, LLC.
KW - As interfaces
KW - Bio-compatible membranes
KW - Biological tissues
KW - Characterisation
KW - Hydrophobic surfaces
KW - Implantable devices
KW - Implantable medical devices
KW - Low water
KW - Polydimethylsiloxane PDMS
KW - Polyether urethanes
KW - Polymer backbones
KW - Polyurethane synthesis
KW - Protective barrier
KW - Soft segments
KW - Surface energies
KW - Water permeability
KW - Water uptake
KW - Water-resistant property
KW - Biocompatibility
KW - Biological membranes
KW - Capillarity
KW - Copolymerization
KW - Hydrophobicity
KW - Microchannels
KW - Microphase separation
KW - Polymeric membranes
KW - Polymers
KW - Surface chemistry
KW - Surface tension
KW - Water content
KW - Silicones
KW - copolymer
KW - dimeticone
KW - polyetherurethan
KW - article
KW - biocompatibility
KW - device
KW - elasticity
KW - encapsulation
KW - energy
KW - hydrophobicity
KW - implant
KW - membrane permeability
KW - priority journal
KW - synthesis
KW - tensile strength
KW - thermal analysis
KW - water permeability
KW - water transport
KW - Calorimetry, Differential Scanning
KW - Dimethylpolysiloxanes
KW - Elasticity
KW - Light
KW - Magnetic Resonance Spectroscopy
KW - Materials Testing
KW - Polyurethanes
KW - Prostheses and Implants
KW - Scattering, Radiation
KW - Spectroscopy, Fourier Transform Infrared
KW - Spectrum Analysis, Raman
KW - Stress, Mechanical
KW - Tensile Strength
KW - Water
U2 - 10.1007/s10856-009-3754-9
DO - 10.1007/s10856-009-3754-9
M3 - Journal article
VL - 20
SP - 1803
EP - 1814
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 9
ER -