Synthesis and characterisation of magnesium substituted calcium phosphate bioceramic nanoparticles made via continuous hydrothermal flow synthesis

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https://doi.org/10.1039/b807920j
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Synthesis and characterisation of magnesium substituted calcium phosphate bioceramic nanoparticles made via continuous hydrothermal flow synthesis. / Chaudhry, A.A.; Goodall, J.; Vickers, M. et al.
In: Journal of Materials Chemistry, Vol. 18, No. 48, 2008, p. 5900-5908.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{6d58b03dfbd04928bb799e1180645273,

title = "Synthesis and characterisation of magnesium substituted calcium phosphate bioceramic nanoparticles made via continuous hydrothermal flow synthesis",

abstract = "Continuous hydrothermal flow synthesis (CHFS) technology has been used as an efficient and direct route to produce a range of largely crystalline magnesium substituted calcium phosphate bioceramics. Initially, magnesium substituted hydroxyapatite, Mg-HA, according to the formula [Ca 10-xMgx(PO4)6(OH)2] was prepared in the CHFS system for x = 0.2 [where x:(10 - x) is the Mg:Ca ratio used in the reagents]. Biphasic mixtures of Mg-HA and Mg-whitlockite were obtained corresponding to x values in the range x = 0.4-1.6. The direct synthesis of phase pure crystalline Mg-whitlockite [based on the formula (Ca3-yMgy(HPO4)z(PO 4)2-2z/3] was also achieved using the CHFS system for the range y = 0.7-1.6 (this corresponds to the range x = 1.6-5.3). With increasing substitution of magnesium for calcium, the material became ever more amorphous and the BET surface area generally increased. All the as-precipitated powders (without any additional heat treatments) were analyzed using techniques including X-ray powder diffraction, Raman spectroscopy and Fourier transform infra-red spectroscopy. Transmission electron microscopy (TEM) images revealed that in the case of y = 1.2, the Mg-whitlockite material comprised of ca. 28 nm sized spheres. The use of the CHFS system in this context facilitated rapid production of combinations of particle properties (crystallinity, size, shape) that were hitherto unobtainable in a single step process. {\textcopyright} The Royal Society of Chemistry 2008.",

keywords = "Bioceramics, Biological materials, Calcium, Calcium alloys, Calcium phosphate, Crystalline materials, Electron holography, Fourier transforms, Heat treatment, Hydrothermal synthesis, Hydroxyapatite, Hydroxylation, Light metals, Magnesium, Phosphates, Powders, Additional heats, BET Surface areas, Biphasic mixtures, Characterisation, Crystallinity, Direct routes, Direct syntheses, Hydrothermal flows, Particle properties, Powder diffractions, Single steps, Magnesium printing plates",

author = "A.A. Chaudhry and J. Goodall and M. Vickers and J.K. Cockcroft and I. Rehman and J.C. Knowles and J.A. Darr",

year = "2008",

doi = "10.1039/b807920j",

language = "English",

volume = "18",

pages = "5900--5908",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

number = "48",

}

RIS

TY - JOUR

T1 - Synthesis and characterisation of magnesium substituted calcium phosphate bioceramic nanoparticles made via continuous hydrothermal flow synthesis

AU - Chaudhry, A.A.

AU - Goodall, J.

AU - Vickers, M.

AU - Cockcroft, J.K.

AU - Rehman, I.

AU - Knowles, J.C.

AU - Darr, J.A.

PY - 2008

Y1 - 2008

N2 - Continuous hydrothermal flow synthesis (CHFS) technology has been used as an efficient and direct route to produce a range of largely crystalline magnesium substituted calcium phosphate bioceramics. Initially, magnesium substituted hydroxyapatite, Mg-HA, according to the formula [Ca 10-xMgx(PO4)6(OH)2] was prepared in the CHFS system for x = 0.2 [where x:(10 - x) is the Mg:Ca ratio used in the reagents]. Biphasic mixtures of Mg-HA and Mg-whitlockite were obtained corresponding to x values in the range x = 0.4-1.6. The direct synthesis of phase pure crystalline Mg-whitlockite [based on the formula (Ca3-yMgy(HPO4)z(PO 4)2-2z/3] was also achieved using the CHFS system for the range y = 0.7-1.6 (this corresponds to the range x = 1.6-5.3). With increasing substitution of magnesium for calcium, the material became ever more amorphous and the BET surface area generally increased. All the as-precipitated powders (without any additional heat treatments) were analyzed using techniques including X-ray powder diffraction, Raman spectroscopy and Fourier transform infra-red spectroscopy. Transmission electron microscopy (TEM) images revealed that in the case of y = 1.2, the Mg-whitlockite material comprised of ca. 28 nm sized spheres. The use of the CHFS system in this context facilitated rapid production of combinations of particle properties (crystallinity, size, shape) that were hitherto unobtainable in a single step process. © The Royal Society of Chemistry 2008.

AB - Continuous hydrothermal flow synthesis (CHFS) technology has been used as an efficient and direct route to produce a range of largely crystalline magnesium substituted calcium phosphate bioceramics. Initially, magnesium substituted hydroxyapatite, Mg-HA, according to the formula [Ca 10-xMgx(PO4)6(OH)2] was prepared in the CHFS system for x = 0.2 [where x:(10 - x) is the Mg:Ca ratio used in the reagents]. Biphasic mixtures of Mg-HA and Mg-whitlockite were obtained corresponding to x values in the range x = 0.4-1.6. The direct synthesis of phase pure crystalline Mg-whitlockite [based on the formula (Ca3-yMgy(HPO4)z(PO 4)2-2z/3] was also achieved using the CHFS system for the range y = 0.7-1.6 (this corresponds to the range x = 1.6-5.3). With increasing substitution of magnesium for calcium, the material became ever more amorphous and the BET surface area generally increased. All the as-precipitated powders (without any additional heat treatments) were analyzed using techniques including X-ray powder diffraction, Raman spectroscopy and Fourier transform infra-red spectroscopy. Transmission electron microscopy (TEM) images revealed that in the case of y = 1.2, the Mg-whitlockite material comprised of ca. 28 nm sized spheres. The use of the CHFS system in this context facilitated rapid production of combinations of particle properties (crystallinity, size, shape) that were hitherto unobtainable in a single step process. © The Royal Society of Chemistry 2008.

KW - Bioceramics

KW - Biological materials

KW - Calcium

KW - Calcium alloys

KW - Calcium phosphate

KW - Crystalline materials

KW - Electron holography

KW - Fourier transforms

KW - Heat treatment

KW - Hydrothermal synthesis

KW - Hydroxyapatite

KW - Hydroxylation

KW - Light metals

KW - Magnesium

KW - Phosphates

KW - Powders

KW - Additional heats

KW - BET Surface areas

KW - Biphasic mixtures

KW - Characterisation

KW - Crystallinity

KW - Direct routes

KW - Direct syntheses

KW - Hydrothermal flows

KW - Particle properties

KW - Powder diffractions

KW - Single steps

KW - Magnesium printing plates

U2 - 10.1039/b807920j

DO - 10.1039/b807920j

M3 - Journal article

VL - 18

SP - 5900

EP - 5908

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

SN - 0959-9428

IS - 48

ER -

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