TY - JOUR

T1 - Synthesis and characterization of a novel fast-set proline-derivative-containing glass ionomer cement with enhanced mechanical properties

AU - Moshaverinia, A.

AU - Roohpour, N.

AU - Rehman, I.U.

PY - 2009

Y1 - 2009

N2 - In this study, a methacryloyl derivative of l-proline was synthesized, characterized and incorporated into a conventional glass ionomer cement (GIC) with a polyacid composition. Subsequently, the effects of incorporation of synthesized N-methacryloyl-proline and terpolymer on the GIC's mechanical and working properties were studied. 1-Methacryloylpyrrolidone-2-carboxylic acid was synthesized and used in a polymerization reaction with acrylic acid and itaconic acid in order to form terpolymer which was used in Fuji II commercial GIC formulations. Chemical structural characterization of the resulting products was performed using 1H nuclear magnetic resonance and Fourier transform infrared spectroscopy. The viscosity and molecular weight of the terpolymer were also measured. The mechanical strength properties of the modified GICs were evaluated after 24 h or 1 week of immersion in distilled water at 37 °C. Analysis of variance was used to study the statistical significance of the mechanical strengths and working properties, and to compare them with a control group. Results showed that N-methacryloyl-proline modified GICs exhibited significantly higher compressive strength (CS; 195-210 MPa), higher diametral tensile strength (DTS; 19-26 MPa) and higher biaxial flexural strength (38-46 MPa) in comparison to Fuji II GIC (161-166 MPa in CS, 12-14 MPa in DTS and 13-18 MPa in biaxial flexural strength). The working properties (setting and working time) of the modified samples showed that the modified cement was a fast-set cement. It was concluded that a novel amino acid-containing GIC has been developed in this study with 27%, 94% and 170% increases in values for compressive, diametral tensile and biaxial flexural strength, respectively, in comparison to commercial Fuji II GIC. © 2008 Acta Materialia Inc.

AB - In this study, a methacryloyl derivative of l-proline was synthesized, characterized and incorporated into a conventional glass ionomer cement (GIC) with a polyacid composition. Subsequently, the effects of incorporation of synthesized N-methacryloyl-proline and terpolymer on the GIC's mechanical and working properties were studied. 1-Methacryloylpyrrolidone-2-carboxylic acid was synthesized and used in a polymerization reaction with acrylic acid and itaconic acid in order to form terpolymer which was used in Fuji II commercial GIC formulations. Chemical structural characterization of the resulting products was performed using 1H nuclear magnetic resonance and Fourier transform infrared spectroscopy. The viscosity and molecular weight of the terpolymer were also measured. The mechanical strength properties of the modified GICs were evaluated after 24 h or 1 week of immersion in distilled water at 37 °C. Analysis of variance was used to study the statistical significance of the mechanical strengths and working properties, and to compare them with a control group. Results showed that N-methacryloyl-proline modified GICs exhibited significantly higher compressive strength (CS; 195-210 MPa), higher diametral tensile strength (DTS; 19-26 MPa) and higher biaxial flexural strength (38-46 MPa) in comparison to Fuji II GIC (161-166 MPa in CS, 12-14 MPa in DTS and 13-18 MPa in biaxial flexural strength). The working properties (setting and working time) of the modified samples showed that the modified cement was a fast-set cement. It was concluded that a novel amino acid-containing GIC has been developed in this study with 27%, 94% and 170% increases in values for compressive, diametral tensile and biaxial flexural strength, respectively, in comparison to commercial Fuji II GIC. © 2008 Acta Materialia Inc.

KW - Glass ionomer cements

KW - Mechanical strength

KW - Polyacrylic acid

KW - Proline derivative

KW - Synthesis

KW - acrylic acid

KW - carboxylic acid derivative

KW - glass ionomer

KW - itaconic acid

KW - proline derivative

KW - article

KW - chemical composition

KW - chemical structure

KW - compressive strength

KW - controlled study

KW - infrared spectroscopy

KW - molecular weight

KW - polymerization

KW - priority journal

KW - proton nuclear magnetic resonance

KW - synthesis

KW - tensile strength

KW - viscosity

KW - Compressive Strength

KW - Glass Ionomer Cements

KW - Magnetic Resonance Spectroscopy

KW - Materials Testing

KW - Molecular Weight

KW - Polymers

KW - Pressure

KW - Proline

KW - Spectroscopy, Fourier Transform Infrared

KW - Stress, Mechanical

KW - Temperature

KW - Tensile Strength

KW - Time Factors

KW - Viscosity

KW - Water

U2 - 10.1016/j.actbio.2008.06.011

DO - 10.1016/j.actbio.2008.06.011

M3 - Journal article

VL - 5

SP - 498

EP - 507

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 1

ER -