TY - JOUR

T1 - Synthesis of a proline-modified acrylic acid copolymer in supercritical CO2 for glass-ionomer dental cement applications

AU - Moshaverinia, A.

AU - Roohpour, N.

AU - Darr, J.A.

AU - Rehman, I.U.

PY - 2009

Y1 - 2009

N2 - Supercritical (sc-) fluids (such as sc-CO2) represent interesting media for the synthesis of polymers in dental and biomedical applications. Sc-CO2 has several advantages for polymerization reactions in comparison to conventional organic solvents. It has several advantages in comparison to conventional polymerization solvents, such as enhanced kinetics, being less harmful to the environment and simplified solvent removal process. In our previous work, we synthesized poly(acrylic acid-co-itaconic acid-co-N-vinylpyrrolidone) (PAA-IA-NVP) terpolymers in a supercritical CO2/methanol mixture for applications in glass-ionomer dental cements. In this study, proline-containing acrylic acid copolymers were synthesized, in a supercritical CO2 mixture or in water. Subsequently, the synthesized polymers were used in commercially available glass-ionomer cement formulations (Fuji IX commercial GIC). Mechanical strength (compressive strength (CS), diametral tensile strength (DTS) and biaxial flexural strength (BFS)) and handling properties (working and setting time) of the resulting modified cements were evaluated. It was found that the polymerization reaction in an sc-CO2/methanol mixture was significantly faster than the corresponding polymerization reaction in water and the purification procedures were simpler for the former. Furthermore, glass-ionomer cement samples made from the terpolymer prepared in sc-CO2/methanol exhibited higher CS and DTS and comparable BFS compared to the same polymer synthesized in water. The working properties of glass-ionomer formulations made in sc-CO2/methanol were comparable and better than the values of those for polymers synthesized in water. © 2009 Acta Materialia Inc.

AB - Supercritical (sc-) fluids (such as sc-CO2) represent interesting media for the synthesis of polymers in dental and biomedical applications. Sc-CO2 has several advantages for polymerization reactions in comparison to conventional organic solvents. It has several advantages in comparison to conventional polymerization solvents, such as enhanced kinetics, being less harmful to the environment and simplified solvent removal process. In our previous work, we synthesized poly(acrylic acid-co-itaconic acid-co-N-vinylpyrrolidone) (PAA-IA-NVP) terpolymers in a supercritical CO2/methanol mixture for applications in glass-ionomer dental cements. In this study, proline-containing acrylic acid copolymers were synthesized, in a supercritical CO2 mixture or in water. Subsequently, the synthesized polymers were used in commercially available glass-ionomer cement formulations (Fuji IX commercial GIC). Mechanical strength (compressive strength (CS), diametral tensile strength (DTS) and biaxial flexural strength (BFS)) and handling properties (working and setting time) of the resulting modified cements were evaluated. It was found that the polymerization reaction in an sc-CO2/methanol mixture was significantly faster than the corresponding polymerization reaction in water and the purification procedures were simpler for the former. Furthermore, glass-ionomer cement samples made from the terpolymer prepared in sc-CO2/methanol exhibited higher CS and DTS and comparable BFS compared to the same polymer synthesized in water. The working properties of glass-ionomer formulations made in sc-CO2/methanol were comparable and better than the values of those for polymers synthesized in water. © 2009 Acta Materialia Inc.

KW - Free radical polymerization

KW - Glass-ionomer cements

KW - Mechanical properties

KW - Proline-amide-modified polyacids

KW - Supercritical CO2

KW - acrylic acid

KW - carbon dioxide

KW - copolymer

KW - glass ionomer

KW - methanol

KW - proline

KW - tooth cement

KW - water

KW - article

KW - biomechanics

KW - chemical reaction

KW - compressive strength

KW - controlled study

KW - polymerization

KW - priority journal

KW - purification

KW - supercritical fluid

KW - tensile strength

KW - Acrylates

KW - Carbon Dioxide

KW - Compressive Strength

KW - Glass Ionomer Cements

KW - Magnetic Resonance Spectroscopy

KW - Materials Testing

KW - Molecular Weight

KW - Polymers

KW - Proline

KW - Spectroscopy, Fourier Transform Infrared

KW - Tensile Strength

KW - Time Factors

KW - Transition Temperature

KW - Water

KW - Paa

U2 - 10.1016/j.actbio.2009.01.037

DO - 10.1016/j.actbio.2009.01.037

M3 - Journal article

VL - 5

SP - 1656

EP - 1662

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 5

ER -