Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.9b00086
Accepted author manuscript, 808 KB, PDF document
Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Letter › peer-review
| <mark>Journal publication date</mark> | 5/04/2019 |
|---|---|
| <mark>Journal</mark> | Organic Letters |
| Issue number | 7 |
| Volume | 21 |
| Number of pages | 4 |
| Pages (from-to) | 2004-2007 |
| Publication Status | Published |
| Early online date | 12/03/19 |
| <mark>Original language</mark> | English |
Anhydrouridines react with aliphatic amines to give N-alkyl isocytosines, but reported procedures often demand very long reaction times and can be low yielding, with narrow scope. A modified procedure for such reactions has been developed, using microwave irradiation, significantly reducing reaction time and allowing facile access to a diverse range of novel nucleosides on the gram scale. The method has been used to prepare a precursor to a novel analogue of lysidine, a naturally occurring iminonucleoside found in (t)RNA.