Synthesis of hybrid polymer networks of irradiated chitosan/poly(vinyl alcohol) for biomedical applications

School of Engineering

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https://doi.org/10.1016/j.radphyschem.2013.09.009
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Synthesis of hybrid polymer networks of irradiated chitosan/poly(vinyl alcohol) for biomedical applications. / Islam, A.; Yasin, T.; Rehman, I.U.
In: Radiation Physics and Chemistry, Vol. 96, 2014, p. 115-119.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{a836c96dcdec4277803bdfd4fd387e62,

title = "Synthesis of hybrid polymer networks of irradiated chitosan/poly(vinyl alcohol) for biomedical applications",

abstract = "Hybrid polymer network (HPN) of chitosan (CS) with poly(vinyl alcohol) (PVA) was prepared by using radiation degraded chitosan. The chemical structure of chitosan promoted chain scission reactions upon irradiation which lowered its molecular weight and also changed its hydrophilic balance. The effect of molecular weight and hydrophilicity of irradiated chitosan on structural, thermal and surface properties of the HPN were studied. The increased hydrophilicity of irradiated chitosan lowered the crystallinity of the HPN. The endothermic peak was shifted towards higher temperatures in HPN having irradiated chitosan. The decreased value of contact angle with increasing dose, further confirmed the increased hydrophilicity of the HPN. The cytotoxicity results of HPN showed the viability of human fibroblast cells and their non-toxic nature making it suitable for tissue engineering and other biomedical applications. {\textcopyright} 2013 Elsevier Ltd.",

keywords = "Biomedical applications, Chain scission, Chitosan, Radiation, Chain-scission reactions, Crystallinities, Endothermic peaks, Human fibroblast cells, Hybrid polymer network, Poly (vinyl alcohol) (PVA), Cell culture, Chains, Heat radiation, Hydrophilicity, Medical applications, Molecular weight, Tissue engineering, Functional polymers, chitosan, hybrid polymer network, hydrogen, hydroxyl radical, polymer, polyvinyl alcohol, unclassified drug, article, biocompatibility, biodegradation, cell proliferation, cell viability, controlled study, crystal structure, cytotoxicity test, fibroblast culture, gamma irradiation, human, human cell, hydrophilicity, medical technology, molecular weight, polymerization, solubility, structure analysis, surface property, viscosity, X ray diffraction",

author = "A. Islam and T. Yasin and I.U. Rehman",

year = "2014",

doi = "10.1016/j.radphyschem.2013.09.009",

language = "English",

volume = "96",

pages = "115--119",

journal = "Radiation Physics and Chemistry",

issn = "0969-806X",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Synthesis of hybrid polymer networks of irradiated chitosan/poly(vinyl alcohol) for biomedical applications

AU - Islam, A.

AU - Yasin, T.

AU - Rehman, I.U.

PY - 2014

Y1 - 2014

N2 - Hybrid polymer network (HPN) of chitosan (CS) with poly(vinyl alcohol) (PVA) was prepared by using radiation degraded chitosan. The chemical structure of chitosan promoted chain scission reactions upon irradiation which lowered its molecular weight and also changed its hydrophilic balance. The effect of molecular weight and hydrophilicity of irradiated chitosan on structural, thermal and surface properties of the HPN were studied. The increased hydrophilicity of irradiated chitosan lowered the crystallinity of the HPN. The endothermic peak was shifted towards higher temperatures in HPN having irradiated chitosan. The decreased value of contact angle with increasing dose, further confirmed the increased hydrophilicity of the HPN. The cytotoxicity results of HPN showed the viability of human fibroblast cells and their non-toxic nature making it suitable for tissue engineering and other biomedical applications. © 2013 Elsevier Ltd.

AB - Hybrid polymer network (HPN) of chitosan (CS) with poly(vinyl alcohol) (PVA) was prepared by using radiation degraded chitosan. The chemical structure of chitosan promoted chain scission reactions upon irradiation which lowered its molecular weight and also changed its hydrophilic balance. The effect of molecular weight and hydrophilicity of irradiated chitosan on structural, thermal and surface properties of the HPN were studied. The increased hydrophilicity of irradiated chitosan lowered the crystallinity of the HPN. The endothermic peak was shifted towards higher temperatures in HPN having irradiated chitosan. The decreased value of contact angle with increasing dose, further confirmed the increased hydrophilicity of the HPN. The cytotoxicity results of HPN showed the viability of human fibroblast cells and their non-toxic nature making it suitable for tissue engineering and other biomedical applications. © 2013 Elsevier Ltd.

KW - Biomedical applications

KW - Chain scission

KW - Chitosan

KW - Radiation

KW - Chain-scission reactions

KW - Crystallinities

KW - Endothermic peaks

KW - Human fibroblast cells

KW - Hybrid polymer network

KW - Poly (vinyl alcohol) (PVA)

KW - Cell culture

KW - Chains

KW - Heat radiation

KW - Hydrophilicity

KW - Medical applications

KW - Molecular weight

KW - Tissue engineering

KW - Functional polymers

KW - chitosan

KW - hybrid polymer network

KW - hydrogen

KW - hydroxyl radical

KW - polymer

KW - polyvinyl alcohol

KW - unclassified drug

KW - article

KW - biocompatibility

KW - biodegradation

KW - cell proliferation

KW - cell viability

KW - controlled study

KW - crystal structure

KW - cytotoxicity test

KW - fibroblast culture

KW - gamma irradiation

KW - human

KW - human cell

KW - hydrophilicity

KW - medical technology

KW - molecular weight

KW - polymerization

KW - solubility

KW - structure analysis

KW - surface property

KW - viscosity

KW - X ray diffraction

U2 - 10.1016/j.radphyschem.2013.09.009

DO - 10.1016/j.radphyschem.2013.09.009

M3 - Journal article

VL - 96

SP - 115

EP - 119

JO - Radiation Physics and Chemistry

JF - Radiation Physics and Chemistry

SN - 0969-806X

ER -

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