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Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. / Abdelwahab, Nuha Z.; Urbaniak, Michael D.; Ferguson, Michael A. J. et al.
In: Carbohydrate Research, Vol. 346, No. 6, 01.05.2011, p. 708-714.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Abdelwahab, NZ, Urbaniak, MD, Ferguson, MAJ & Crossman, AT 2011, 'Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei', Carbohydrate Research, vol. 346, no. 6, pp. 708-714. https://doi.org/10.1016/j.carres.2011.02.004

APA

Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J., & Crossman, A. T. (2011). Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. Carbohydrate Research, 346(6), 708-714. https://doi.org/10.1016/j.carres.2011.02.004

Vancouver

Abdelwahab NZ, Urbaniak MD, Ferguson MAJ, Crossman AT. Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. Carbohydrate Research. 2011 May 1;346(6):708-714. doi: 10.1016/j.carres.2011.02.004

Author

Abdelwahab, Nuha Z. ; Urbaniak, Michael D. ; Ferguson, Michael A. J. et al. / Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. In: Carbohydrate Research. 2011 ; Vol. 346, No. 6. pp. 708-714.

Bibtex

@article{5e11e0ed16a341759f33904a03032581,
title = "Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei",
abstract = "A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.",
keywords = "Acetylesterase, Enzyme Inhibitors, Glycosylphosphatidylinositols, Magnetic Resonance Spectroscopy, Metalloproteins, Molecular Structure, Trypanosoma brucei brucei, Zinc",
author = "Abdelwahab, {Nuha Z.} and Urbaniak, {Michael D.} and Ferguson, {Michael A. J.} and Crossman, {Arthur T.}",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
month = may,
day = "1",
doi = "10.1016/j.carres.2011.02.004",
language = "English",
volume = "346",
pages = "708--714",
journal = "Carbohydrate Research",
issn = "0008-6215",
publisher = "Elsevier BV",
number = "6",

}

RIS

TY - JOUR

T1 - Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

AU - Abdelwahab, Nuha Z.

AU - Urbaniak, Michael D.

AU - Ferguson, Michael A. J.

AU - Crossman, Arthur T.

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.

AB - A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.

KW - Acetylesterase

KW - Enzyme Inhibitors

KW - Glycosylphosphatidylinositols

KW - Magnetic Resonance Spectroscopy

KW - Metalloproteins

KW - Molecular Structure

KW - Trypanosoma brucei brucei

KW - Zinc

U2 - 10.1016/j.carres.2011.02.004

DO - 10.1016/j.carres.2011.02.004

M3 - Journal article

C2 - 21377660

VL - 346

SP - 708

EP - 714

JO - Carbohydrate Research

JF - Carbohydrate Research

SN - 0008-6215

IS - 6

ER -