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Synthetic glycovaccine protects against the bite of leishmania-infected sand flies

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Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. / Rogers, Matthew E; Sizova, Olga V; Ferguson, Michael A J; Nikolaev, Andrei V; Bates, Paul A.

In: Journal of Infectious Diseases, Vol. 194, No. 4, 2006, p. 512-518.

Research output: Contribution to journalJournal article

Harvard

Rogers, ME, Sizova, OV, Ferguson, MAJ, Nikolaev, AV & Bates, PA 2006, 'Synthetic glycovaccine protects against the bite of leishmania-infected sand flies', Journal of Infectious Diseases, vol. 194, no. 4, pp. 512-518. https://doi.org/10.1086/505584

APA

Rogers, M. E., Sizova, O. V., Ferguson, M. A. J., Nikolaev, A. V., & Bates, P. A. (2006). Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. Journal of Infectious Diseases, 194(4), 512-518. https://doi.org/10.1086/505584

Vancouver

Rogers ME, Sizova OV, Ferguson MAJ, Nikolaev AV, Bates PA. Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. Journal of Infectious Diseases. 2006;194(4):512-518. https://doi.org/10.1086/505584

Author

Rogers, Matthew E ; Sizova, Olga V ; Ferguson, Michael A J ; Nikolaev, Andrei V ; Bates, Paul A. / Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. In: Journal of Infectious Diseases. 2006 ; Vol. 194, No. 4. pp. 512-518.

Bibtex

@article{013c536cfad147eab1aef6519b90df0b,
title = "Synthetic glycovaccine protects against the bite of leishmania-infected sand flies",
abstract = "Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic glycovaccine containing the glycans found in L. mexicana PSG can provide significant protection against challenge by the bite of infected sand flies. Only the glycan from L. mexicana was protective; those from other species did not protect against L. mexicana infection. Furthermore, neither PSG nor the glycovaccine protected against artificial needle challenge, which is traditionally used in antileishmanial vaccine development. Conversely, an antigen preparation that was effective against needle challenge offered no protection against sand fly bite. These findings provide a new target for Leishmania vaccine development and demonstrate the critical role that the vector plays in the evaluation of candidate vaccines for leishmaniasis and other vectorborne diseases.",
author = "Rogers, {Matthew E} and Sizova, {Olga V} and Ferguson, {Michael A J} and Nikolaev, {Andrei V} and Bates, {Paul A}",
year = "2006",
doi = "10.1086/505584",
language = "English",
volume = "194",
pages = "512--518",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Synthetic glycovaccine protects against the bite of leishmania-infected sand flies

AU - Rogers, Matthew E

AU - Sizova, Olga V

AU - Ferguson, Michael A J

AU - Nikolaev, Andrei V

AU - Bates, Paul A

PY - 2006

Y1 - 2006

N2 - Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic glycovaccine containing the glycans found in L. mexicana PSG can provide significant protection against challenge by the bite of infected sand flies. Only the glycan from L. mexicana was protective; those from other species did not protect against L. mexicana infection. Furthermore, neither PSG nor the glycovaccine protected against artificial needle challenge, which is traditionally used in antileishmanial vaccine development. Conversely, an antigen preparation that was effective against needle challenge offered no protection against sand fly bite. These findings provide a new target for Leishmania vaccine development and demonstrate the critical role that the vector plays in the evaluation of candidate vaccines for leishmaniasis and other vectorborne diseases.

AB - Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic glycovaccine containing the glycans found in L. mexicana PSG can provide significant protection against challenge by the bite of infected sand flies. Only the glycan from L. mexicana was protective; those from other species did not protect against L. mexicana infection. Furthermore, neither PSG nor the glycovaccine protected against artificial needle challenge, which is traditionally used in antileishmanial vaccine development. Conversely, an antigen preparation that was effective against needle challenge offered no protection against sand fly bite. These findings provide a new target for Leishmania vaccine development and demonstrate the critical role that the vector plays in the evaluation of candidate vaccines for leishmaniasis and other vectorborne diseases.

U2 - 10.1086/505584

DO - 10.1086/505584

M3 - Journal article

C2 - 16845636

VL - 194

SP - 512

EP - 518

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -