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System identification of metabotropic glutamate receptor dependent long–term depression

Research output: Contribution to journalJournal article


<mark>Journal publication date</mark>2013
<mark>Journal</mark>Neural Computation
Issue number3
Number of pages21
Pages (from-to)650-670
<mark>Original language</mark>English


Recent advances have started to uncover the underlying mechanisms of metabotropic glutamate receptor (mGluR) dependent long-term depression (LTD). However, it is not completely clear how these mechanisms are linked and it is believed that several crucial mechanisms still remain to be revealed. In this study, we investigated whether system identification (SI) methods can be used to gain insight into the mechanisms of synaptic plasticity. SI methods have shown to be an objective and powerful approach for describing how sensory neurons encode information about stimuli. However, to the author’s knowledge it is the first time that SI methods are applied on electrophysiological brain slice recordings of synaptic plasticity responses. The results indicate that the SI approach is a valuable tool for reverse engineering of mGluR-LTD responses. It is suggested that such SI methods can aid to unravel the complexities of synaptic function.