Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - The action of a mast cell protease on the cuticular collagens of Necator americanus.
AU - McKean, Paul G.
AU - Pritchard, D. I.
PY - 1989/5
Y1 - 1989/5
N2 - Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.
AB - Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.
U2 - 10.1111/j.1365-3024.1989.tb00667.x
DO - 10.1111/j.1365-3024.1989.tb00667.x
M3 - Journal article
VL - 11
SP - 293
EP - 297
JO - Parasite Immunology
JF - Parasite Immunology
SN - 1365-3024
IS - 3
ER -