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The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

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The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. / Brookes, K.; Xu, X.; Chen, W. et al.
In: Molecular Psychiatry, Vol. 11, No. 10, 10.2006, p. 934-953.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Brookes, K, Xu, X, Chen, W, Zhou, K, Neale, B, Lowe, N, Anney, R, Franke, B, Gill, M, Ebstein, R, Buitelaar, J, Sham, P, Campbell, D, Knight, J, Andreou, P, Altink, M, Arnold, R, Boer, F, Buschgens, C, Butler, L, Christiansen, H, Feldman, L, Fleischman, K, Fliers, E, Howe-Forbes, R, Goldfarb, A, Heise, A, Gabriëls, I, Korn-Lubetzki, I, Johansson, L, Marco, R, Medad, S, Minderaa, R, Mulas, F, Müller, U, Mulligan, A, Rabin, K, Rommelse, N, Sethna, V, Sorohan, J, Uebel, H, Psychogiou, L, Weeks, A, Barrett, R, Craig, I, Banaschewski, T, Sonuga-Barke, E, Eisenberg, J, Kuntsi, J, Manor, I, McGuffin, P, Miranda, A, Oades, RD, Plomin, R, Roeyers, H, Rothenberger, A, Sergeant, J, Steinhausen, H-C, Taylor, E, Thompson, M, Faraone, SV & Asherson, P 2006, 'The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes', Molecular Psychiatry, vol. 11, no. 10, pp. 934-953. https://doi.org/10.1038/sj.mp.4001869

APA

Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Anney, R., Franke, B., Gill, M., Ebstein, R., Buitelaar, J., Sham, P., Campbell, D., Knight, J., Andreou, P., Altink, M., Arnold, R., Boer, F., Buschgens, C., ... Asherson, P. (2006). The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Molecular Psychiatry, 11(10), 934-953. https://doi.org/10.1038/sj.mp.4001869

Vancouver

Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N et al. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Molecular Psychiatry. 2006 Oct;11(10):934-953. Epub 2006 Aug 8. doi: 10.1038/sj.mp.4001869

Author

Brookes, K. ; Xu, X. ; Chen, W. et al. / The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder : association signals in DRD4, DAT1 and 16 other genes. In: Molecular Psychiatry. 2006 ; Vol. 11, No. 10. pp. 934-953.

Bibtex

@article{0a864fef86ff4f6881b5b840727faf3b,
title = "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes",
abstract = "Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples.",
keywords = "Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Dopamine Plasma Membrane Transport Proteins, Genetic Markers, Genetic Predisposition to Disease, Haplotypes, Humans, Linkage Disequilibrium, Monoamine Oxidase, Oncogene Proteins, Pedigree, Polymorphism, Single Nucleotide, Receptors, Dopamine D4, Receptors, Nicotinic, Siblings, Synaptosomal-Associated Protein 25, Tryptophan Hydroxylase",
author = "K. Brookes and X. Xu and W. Chen and Kaixin Zhou and Ben Neale and N. Lowe and R. Anney and B. Franke and M. Gill and Richard Ebstein and Jan Buitelaar and P Sham and D. Campbell and Jo Knight and Penny Andreou and Marieke Altink and R. Arnold and F Boer and C Buschgens and L Butler and H Christiansen and L Feldman and K Fleischman and E Fliers and R Howe-Forbes and A Goldfarb and A Heise and I Gabri{\"e}ls and I Korn-Lubetzki and L Johansson and R Marco and S Medad and R Minderaa and F Mulas and U M{\"u}ller and A Mulligan and K Rabin and N Rommelse and V Sethna and J Sorohan and H Uebel and L Psychogiou and A Weeks and R Barrett and I Craig and T Banaschewski and E Sonuga-Barke and J Eisenberg and J Kuntsi and I Manor and P McGuffin and A Miranda and Oades, {R D} and R Plomin and H Roeyers and A Rothenberger and J Sergeant and H-C Steinhausen and E Taylor and M Thompson and Faraone, {S V} and P Asherson",
year = "2006",
month = oct,
doi = "10.1038/sj.mp.4001869",
language = "English",
volume = "11",
pages = "934--953",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder

T2 - association signals in DRD4, DAT1 and 16 other genes

AU - Brookes, K.

AU - Xu, X.

AU - Chen, W.

AU - Zhou, Kaixin

AU - Neale, Ben

AU - Lowe, N.

AU - Anney, R.

AU - Franke, B.

AU - Gill, M.

AU - Ebstein, Richard

AU - Buitelaar, Jan

AU - Sham, P

AU - Campbell, D.

AU - Knight, Jo

AU - Andreou, Penny

AU - Altink, Marieke

AU - Arnold, R.

AU - Boer, F

AU - Buschgens, C

AU - Butler, L

AU - Christiansen, H

AU - Feldman, L

AU - Fleischman, K

AU - Fliers, E

AU - Howe-Forbes, R

AU - Goldfarb, A

AU - Heise, A

AU - Gabriëls, I

AU - Korn-Lubetzki, I

AU - Johansson, L

AU - Marco, R

AU - Medad, S

AU - Minderaa, R

AU - Mulas, F

AU - Müller, U

AU - Mulligan, A

AU - Rabin, K

AU - Rommelse, N

AU - Sethna, V

AU - Sorohan, J

AU - Uebel, H

AU - Psychogiou, L

AU - Weeks, A

AU - Barrett, R

AU - Craig, I

AU - Banaschewski, T

AU - Sonuga-Barke, E

AU - Eisenberg, J

AU - Kuntsi, J

AU - Manor, I

AU - McGuffin, P

AU - Miranda, A

AU - Oades, R D

AU - Plomin, R

AU - Roeyers, H

AU - Rothenberger, A

AU - Sergeant, J

AU - Steinhausen, H-C

AU - Taylor, E

AU - Thompson, M

AU - Faraone, S V

AU - Asherson, P

PY - 2006/10

Y1 - 2006/10

N2 - Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples.

AB - Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples.

KW - Adolescent

KW - Attention Deficit Disorder with Hyperactivity

KW - Child

KW - Child, Preschool

KW - Dopamine Plasma Membrane Transport Proteins

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Monoamine Oxidase

KW - Oncogene Proteins

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Receptors, Dopamine D4

KW - Receptors, Nicotinic

KW - Siblings

KW - Synaptosomal-Associated Protein 25

KW - Tryptophan Hydroxylase

U2 - 10.1038/sj.mp.4001869

DO - 10.1038/sj.mp.4001869

M3 - Journal article

C2 - 16894395

VL - 11

SP - 934

EP - 953

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 10

ER -