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The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study

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The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study. / Aldekhail, N M; Morrison, D S; Khojah, H et al.
In: Diabetic Medicine, Vol. 37, No. 2, 01.02.2020, p. 248-255.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Aldekhail, NM, Morrison, DS, Khojah, H, Sloan, B, McLoone, P, MacNaughton, S, Shearer, R & Logue, J 2020, 'The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study', Diabetic Medicine, vol. 37, no. 2, pp. 248-255. https://doi.org/10.1111/dme.14093

APA

Aldekhail, N. M., Morrison, D. S., Khojah, H., Sloan, B., McLoone, P., MacNaughton, S., Shearer, R., & Logue, J. (2020). The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study. Diabetic Medicine, 37(2), 248-255. https://doi.org/10.1111/dme.14093

Vancouver

Aldekhail NM, Morrison DS, Khojah H, Sloan B, McLoone P, MacNaughton S et al. The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study. Diabetic Medicine. 2020 Feb 1;37(2):248-255. Epub 2019 Sept 3. doi: 10.1111/dme.14093

Author

Aldekhail, N M ; Morrison, D S ; Khojah, H et al. / The association between diabetes medication and weight change in a non-surgical weight management intervention : an intervention cohort study. In: Diabetic Medicine. 2020 ; Vol. 37, No. 2. pp. 248-255.

Bibtex

@article{4d3a10f7dd114d8f85d0f77a3a046364,
title = "The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study",
abstract = "AIM: To compare weight change in a lifestyle-based weight management programme between participants taking weight-gaining, weight-neutral/loss and mixed diabetes medications.METHODS: Electronic health records for individuals (≥ 18 years) with Type 2 diabetes who had been referred to a non-surgical weight management programme between February 2008 and May 2014 were studied. Diabetes medications were classified into three categories based on their effect on body weight. In this intervention cohort study, weight change was calculated for participants attending two or more sessions.RESULTS: All 998 individuals who took oral diabetes medications and attended two or more sessions of weight management were included. Some 59.5% of participants were women, and participants had a mean BMI of 41.1 kg/m2 (women) and 40.2 kg/m2 (men). Of the diabetes medication combinations prescribed, 46.0% were weight-neutral/loss, 41.3% mixed and 12.7% weight-gaining. The mean weight change for participants on weight-gaining and weight-neutral/loss diabetes medications respectively was -2.5 kg [95% confidence interval (CI) -3.2 to -1.8) and -3.3 kg (95% CI -3.8 to -2.9) (P = 0.05) for those attending two or more sessions (n = 998). Compared with those prescribed weight-neutral medications, participants prescribed weight-gaining medication lost 0.86 kg less (95% CI 0.02 to 1.7; P = 0.045) in a model adjusted for age, sex, BMI and socio-economic status.CONCLUSIONS: Participants on weight-neutral/loss diabetes medications had a greater absolute weight loss within a weight management intervention compared with those on weight-gaining medications. Diabetes medications should be reviewed ahead of planned weight-loss interventions to help ensure maximal effectiveness of the intervention.",
author = "Aldekhail, {N M} and Morrison, {D S} and H Khojah and B Sloan and P McLoone and S MacNaughton and R Shearer and J Logue",
year = "2020",
month = feb,
day = "1",
doi = "10.1111/dme.14093",
language = "English",
volume = "37",
pages = "248--255",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The association between diabetes medication and weight change in a non-surgical weight management intervention

T2 - an intervention cohort study

AU - Aldekhail, N M

AU - Morrison, D S

AU - Khojah, H

AU - Sloan, B

AU - McLoone, P

AU - MacNaughton, S

AU - Shearer, R

AU - Logue, J

PY - 2020/2/1

Y1 - 2020/2/1

N2 - AIM: To compare weight change in a lifestyle-based weight management programme between participants taking weight-gaining, weight-neutral/loss and mixed diabetes medications.METHODS: Electronic health records for individuals (≥ 18 years) with Type 2 diabetes who had been referred to a non-surgical weight management programme between February 2008 and May 2014 were studied. Diabetes medications were classified into three categories based on their effect on body weight. In this intervention cohort study, weight change was calculated for participants attending two or more sessions.RESULTS: All 998 individuals who took oral diabetes medications and attended two or more sessions of weight management were included. Some 59.5% of participants were women, and participants had a mean BMI of 41.1 kg/m2 (women) and 40.2 kg/m2 (men). Of the diabetes medication combinations prescribed, 46.0% were weight-neutral/loss, 41.3% mixed and 12.7% weight-gaining. The mean weight change for participants on weight-gaining and weight-neutral/loss diabetes medications respectively was -2.5 kg [95% confidence interval (CI) -3.2 to -1.8) and -3.3 kg (95% CI -3.8 to -2.9) (P = 0.05) for those attending two or more sessions (n = 998). Compared with those prescribed weight-neutral medications, participants prescribed weight-gaining medication lost 0.86 kg less (95% CI 0.02 to 1.7; P = 0.045) in a model adjusted for age, sex, BMI and socio-economic status.CONCLUSIONS: Participants on weight-neutral/loss diabetes medications had a greater absolute weight loss within a weight management intervention compared with those on weight-gaining medications. Diabetes medications should be reviewed ahead of planned weight-loss interventions to help ensure maximal effectiveness of the intervention.

AB - AIM: To compare weight change in a lifestyle-based weight management programme between participants taking weight-gaining, weight-neutral/loss and mixed diabetes medications.METHODS: Electronic health records for individuals (≥ 18 years) with Type 2 diabetes who had been referred to a non-surgical weight management programme between February 2008 and May 2014 were studied. Diabetes medications were classified into three categories based on their effect on body weight. In this intervention cohort study, weight change was calculated for participants attending two or more sessions.RESULTS: All 998 individuals who took oral diabetes medications and attended two or more sessions of weight management were included. Some 59.5% of participants were women, and participants had a mean BMI of 41.1 kg/m2 (women) and 40.2 kg/m2 (men). Of the diabetes medication combinations prescribed, 46.0% were weight-neutral/loss, 41.3% mixed and 12.7% weight-gaining. The mean weight change for participants on weight-gaining and weight-neutral/loss diabetes medications respectively was -2.5 kg [95% confidence interval (CI) -3.2 to -1.8) and -3.3 kg (95% CI -3.8 to -2.9) (P = 0.05) for those attending two or more sessions (n = 998). Compared with those prescribed weight-neutral medications, participants prescribed weight-gaining medication lost 0.86 kg less (95% CI 0.02 to 1.7; P = 0.045) in a model adjusted for age, sex, BMI and socio-economic status.CONCLUSIONS: Participants on weight-neutral/loss diabetes medications had a greater absolute weight loss within a weight management intervention compared with those on weight-gaining medications. Diabetes medications should be reviewed ahead of planned weight-loss interventions to help ensure maximal effectiveness of the intervention.

U2 - 10.1111/dme.14093

DO - 10.1111/dme.14093

M3 - Journal article

C2 - 31365143

VL - 37

SP - 248

EP - 255

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 2

ER -