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The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds

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The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. / Dewey, Rebecca; Francis, Susan; Guest, Hannah et al.
In: NeuroImage, Vol. 204, 116239, 01.01.2020.

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Dewey R, Francis S, Guest H, Prendergast G, Rebecca M, Plack C et al. The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. NeuroImage. 2020 Jan 1;204:116239. Epub 2019 Oct 3. doi: 10.1016/j.neuroimage.2019.116239

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Dewey, Rebecca ; Francis, Susan ; Guest, Hannah et al. / The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. In: NeuroImage. 2020 ; Vol. 204.

Bibtex

@article{3aa71c2823014d4997a91dddb4e3712d,
title = "The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds",
abstract = "In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several mammalian species, but the hypothesis that lifetime noise exposure affects auditory function in humans with normal audiometric thresholds remains unconfirmed and current evidence from human electrophysiology is contradictory. Here we report the auditory brainstem response (ABR), and both transient (stimulus onset and offset) and sustained functional magnetic resonance imaging (fMRI) responses throughout the human central auditory pathway across lifetime noise exposure. Healthy young individuals aged 25–40 years were recruited into high (n = 32) and low (n = 30) lifetime noise exposure groups, stratified for age, and balanced for audiometric threshold up to 16 kHz fMRI demonstrated robust broadband noise-related activity throughout the auditory pathway (cochlear nucleus, superior olivary complex, nucleus of the lateral lemniscus, inferior colliculus, medial geniculate body and auditory cortex). fMRI responses in the auditory pathway to broadband noise onset were significantly enhanced in the high noise exposure group relative to the low exposure group, differences in sustained fMRI responses did not reach significance, and no significant group differences were found in the click-evoked ABR. Exploratory analyses found no significant relationships between the neural responses and self-reported tinnitus or reduced sound-level tolerance (symptoms associated with synaptopathy). In summary, although a small effect, these fMRI results suggest that lifetime noise exposure may be associated with central hyperactivity in young adults with normal hearing thresholds.",
author = "Rebecca Dewey and Susan Francis and Hannah Guest and Garreth Prendergast and Millman Rebecca and Christopher Plack and Hall, {Deborah A.}",
year = "2020",
month = jan,
day = "1",
doi = "10.1016/j.neuroimage.2019.116239",
language = "English",
volume = "204",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds

AU - Dewey, Rebecca

AU - Francis, Susan

AU - Guest, Hannah

AU - Prendergast, Garreth

AU - Rebecca, Millman

AU - Plack, Christopher

AU - Hall, Deborah A.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several mammalian species, but the hypothesis that lifetime noise exposure affects auditory function in humans with normal audiometric thresholds remains unconfirmed and current evidence from human electrophysiology is contradictory. Here we report the auditory brainstem response (ABR), and both transient (stimulus onset and offset) and sustained functional magnetic resonance imaging (fMRI) responses throughout the human central auditory pathway across lifetime noise exposure. Healthy young individuals aged 25–40 years were recruited into high (n = 32) and low (n = 30) lifetime noise exposure groups, stratified for age, and balanced for audiometric threshold up to 16 kHz fMRI demonstrated robust broadband noise-related activity throughout the auditory pathway (cochlear nucleus, superior olivary complex, nucleus of the lateral lemniscus, inferior colliculus, medial geniculate body and auditory cortex). fMRI responses in the auditory pathway to broadband noise onset were significantly enhanced in the high noise exposure group relative to the low exposure group, differences in sustained fMRI responses did not reach significance, and no significant group differences were found in the click-evoked ABR. Exploratory analyses found no significant relationships between the neural responses and self-reported tinnitus or reduced sound-level tolerance (symptoms associated with synaptopathy). In summary, although a small effect, these fMRI results suggest that lifetime noise exposure may be associated with central hyperactivity in young adults with normal hearing thresholds.

AB - In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several mammalian species, but the hypothesis that lifetime noise exposure affects auditory function in humans with normal audiometric thresholds remains unconfirmed and current evidence from human electrophysiology is contradictory. Here we report the auditory brainstem response (ABR), and both transient (stimulus onset and offset) and sustained functional magnetic resonance imaging (fMRI) responses throughout the human central auditory pathway across lifetime noise exposure. Healthy young individuals aged 25–40 years were recruited into high (n = 32) and low (n = 30) lifetime noise exposure groups, stratified for age, and balanced for audiometric threshold up to 16 kHz fMRI demonstrated robust broadband noise-related activity throughout the auditory pathway (cochlear nucleus, superior olivary complex, nucleus of the lateral lemniscus, inferior colliculus, medial geniculate body and auditory cortex). fMRI responses in the auditory pathway to broadband noise onset were significantly enhanced in the high noise exposure group relative to the low exposure group, differences in sustained fMRI responses did not reach significance, and no significant group differences were found in the click-evoked ABR. Exploratory analyses found no significant relationships between the neural responses and self-reported tinnitus or reduced sound-level tolerance (symptoms associated with synaptopathy). In summary, although a small effect, these fMRI results suggest that lifetime noise exposure may be associated with central hyperactivity in young adults with normal hearing thresholds.

U2 - 10.1016/j.neuroimage.2019.116239

DO - 10.1016/j.neuroimage.2019.116239

M3 - Journal article

VL - 204

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116239

ER -