Rights statement: Copyright © 2015 Crawford, Devereaux, Higham and Kelly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Final published version, 1.65 MB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The disengagement of visual attention in Alzheimer's disease
T2 - a longitudinal eye-tracking study
AU - Crawford, Trevor
AU - Devereaux, Alex
AU - Higham, Steve
AU - Kelly, Claire
N1 - Copyright © 2015 Crawford, Devereaux, Higham and Kelly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
PY - 2015/6/23
Y1 - 2015/6/23
N2 - Introduction: Eye tracking provides a convenient and promising biological marker of cognitive impairment in patients with neurodegenerative disease. Here we report a longitudinal study of saccadic eye movements in a sample of patients with Alzheimer's disease and elderly control participants who were assessed at the start of the study and followed up 12-months later.Methods: Eye movements were measured in the standard gap and overlap paradigms, to examine the longitudinal trends in the ability to disengage attention from a visual target.Results: Overall patients with Alzheimer's disease had slower reaction times than the control group. However, after 12-months, both groups showed faster and comparable reductions in reaction times to the gap, compared to the overlap stimulus. Interestingly, there was a general improvement for both groups with more accurately directed saccades and speeding of reaction times after 12-months.Conclusions: These findings point to the value of longer-term studies and follow-up assessment to ascertain the effects of dementia on oculomotor control.
AB - Introduction: Eye tracking provides a convenient and promising biological marker of cognitive impairment in patients with neurodegenerative disease. Here we report a longitudinal study of saccadic eye movements in a sample of patients with Alzheimer's disease and elderly control participants who were assessed at the start of the study and followed up 12-months later.Methods: Eye movements were measured in the standard gap and overlap paradigms, to examine the longitudinal trends in the ability to disengage attention from a visual target.Results: Overall patients with Alzheimer's disease had slower reaction times than the control group. However, after 12-months, both groups showed faster and comparable reductions in reaction times to the gap, compared to the overlap stimulus. Interestingly, there was a general improvement for both groups with more accurately directed saccades and speeding of reaction times after 12-months.Conclusions: These findings point to the value of longer-term studies and follow-up assessment to ascertain the effects of dementia on oculomotor control.
KW - dementia
KW - eye-tracking
KW - Alzheimer's disease
KW - Attention
KW - cognition
U2 - 10.3389/fnagi.2015.00118
DO - 10.3389/fnagi.2015.00118
M3 - Journal article
VL - 7
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 118
ER -