This work uses a software package created at the University of Sheffield to examine the effects of uncertainties on acoustic emission responses. This software implements a finite difference scheme called the Local Interaction Simulation Approach (LISA) to numerically model acoustic emission waveforms in a given structure. Uncertainties are then introduced into the parameters of this algorithm and the effects on the acoustic emission responses are observed. Finally, acoustic emission testing is performed on a corresponding experimental test structure to ensure that the software predictions are accurate in the presence of uncertainties.