Home > Research > Publications & Outputs > The first Non-LRV RNA virus in leishmania

Links

Text available via DOI:

View graph of relations

The first Non-LRV RNA virus in leishmania

Research output: Contribution to journalJournal article

Published
  • D. Grybchuk
  • D.H. MacEdo
  • Y. Kleschenko
  • N. Kraeva
  • A.N. Lukashev
  • P.A. Bates
  • P. Kulich
  • T. Leštinová
  • P. Volf
  • A.Y. Kostygov
  • V. Yurchenko
Close
Article number168
<mark>Journal publication date</mark>2/02/2020
<mark>Journal</mark>Viruses
Issue number2
Volume12
Number of pages16
Publication statusPublished
Original languageEnglish

Abstract

In this work, we describe the first Leishmania-infecting leishbunyavirus—the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites’ infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.