Home > Research > Publications & Outputs > The genome of Epstein-Barr virus type 2 strain ...

Research

Links

Text available via DOI:

Keywords

View graph of relations

The genome of Epstein-Barr virus type 2 strain AG876

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

The genome of Epstein-Barr virus type 2 strain AG876. / Dolan, Aidan; Addison, Clare; Gatherer, Derek et al.
In: Virology, Vol. 350, No. 1, 20.06.2006, p. 164-170.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Dolan, A, Addison, C, Gatherer, D, Davison, AJ & McGeoch, DJ 2006, 'The genome of Epstein-Barr virus type 2 strain AG876', Virology, vol. 350, no. 1, pp. 164-170. https://doi.org/10.1016/j.virol.2006.01.015

APA

Dolan, A., Addison, C., Gatherer, D., Davison, A. J., & McGeoch, D. J. (2006). The genome of Epstein-Barr virus type 2 strain AG876. Virology, 350(1), 164-170. https://doi.org/10.1016/j.virol.2006.01.015

Vancouver

Dolan A, Addison C, Gatherer D, Davison AJ, McGeoch DJ. The genome of Epstein-Barr virus type 2 strain AG876. Virology. 2006 Jun 20;350(1):164-170. doi: 10.1016/j.virol.2006.01.015

Author

Dolan, Aidan ; Addison, Clare ; Gatherer, Derek et al. / The genome of Epstein-Barr virus type 2 strain AG876. In: Virology. 2006 ; Vol. 350, No. 1. pp. 164-170.

Bibtex

@article{6606c3bdb2bb42528073241e0aefa78a,
title = "The genome of Epstein-Barr virus type 2 strain AG876",
abstract = "Two Epstein-Barr virus (EBV) types are known, EBV1 and EBV2, which possess substantially diverged alleles for latency genes EBNA-2, EBNA-3A, EBNA-3B and EBNA-3C but are thought to be otherwise similar. We report the first complete EBV2 genome sequence, for strain AG876, as 172,764 bp. The sequence was interpreted as containing at least 80 protein coding genes. Comparison with the published EBV1 sequence demonstrated that the two sequences are collinear and, outside the known diverged alleles, generally very close. The EBNA-1 gene was identified as another diverged locus, although its variation is believed not to correlate with EBV type. Patterns of substitution between the two genomes presented a wide spectrum of classes of change. No evidence was seen for involvement of B-cell-specific hypermutation systems in generation of the diverged alleles. Overall, genomic comparisons indicated that the two EBV types should be regarded as belonging to the same virus species. (c) 2006 Elsevier Inc. All rights reserved.",
keywords = "Herpesviridae, Gammaherpesvirinae, Lymphocryptovirus, Human herpesvirus 4, viral genomics, viral evolution, oncogenic virus, viral latency, NUCLEAR ANTIGEN 1, CYTIDINE DEAMINASE AID, DNA-SEQUENCE, INTERTYPIC RECOMBINANTS, LATENT, GENES, EBV, IDENTIFICATION, HYPERMUTATION, REPLICATION",
author = "Aidan Dolan and Clare Addison and Derek Gatherer and Davison, {Andrew J.} and McGeoch, {Duncan J.}",
year = "2006",
month = jun,
day = "20",
doi = "10.1016/j.virol.2006.01.015",
language = "English",
volume = "350",
pages = "164--170",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - The genome of Epstein-Barr virus type 2 strain AG876

AU - Dolan, Aidan

AU - Addison, Clare

AU - Gatherer, Derek

AU - Davison, Andrew J.

AU - McGeoch, Duncan J.

PY - 2006/6/20

Y1 - 2006/6/20

N2 - Two Epstein-Barr virus (EBV) types are known, EBV1 and EBV2, which possess substantially diverged alleles for latency genes EBNA-2, EBNA-3A, EBNA-3B and EBNA-3C but are thought to be otherwise similar. We report the first complete EBV2 genome sequence, for strain AG876, as 172,764 bp. The sequence was interpreted as containing at least 80 protein coding genes. Comparison with the published EBV1 sequence demonstrated that the two sequences are collinear and, outside the known diverged alleles, generally very close. The EBNA-1 gene was identified as another diverged locus, although its variation is believed not to correlate with EBV type. Patterns of substitution between the two genomes presented a wide spectrum of classes of change. No evidence was seen for involvement of B-cell-specific hypermutation systems in generation of the diverged alleles. Overall, genomic comparisons indicated that the two EBV types should be regarded as belonging to the same virus species. (c) 2006 Elsevier Inc. All rights reserved.

AB - Two Epstein-Barr virus (EBV) types are known, EBV1 and EBV2, which possess substantially diverged alleles for latency genes EBNA-2, EBNA-3A, EBNA-3B and EBNA-3C but are thought to be otherwise similar. We report the first complete EBV2 genome sequence, for strain AG876, as 172,764 bp. The sequence was interpreted as containing at least 80 protein coding genes. Comparison with the published EBV1 sequence demonstrated that the two sequences are collinear and, outside the known diverged alleles, generally very close. The EBNA-1 gene was identified as another diverged locus, although its variation is believed not to correlate with EBV type. Patterns of substitution between the two genomes presented a wide spectrum of classes of change. No evidence was seen for involvement of B-cell-specific hypermutation systems in generation of the diverged alleles. Overall, genomic comparisons indicated that the two EBV types should be regarded as belonging to the same virus species. (c) 2006 Elsevier Inc. All rights reserved.

KW - Herpesviridae

KW - Gammaherpesvirinae

KW - Lymphocryptovirus

KW - Human herpesvirus 4

KW - viral genomics

KW - viral evolution

KW - oncogenic virus

KW - viral latency

KW - NUCLEAR ANTIGEN 1

KW - CYTIDINE DEAMINASE AID

KW - DNA-SEQUENCE

KW - INTERTYPIC RECOMBINANTS

KW - LATENT

KW - GENES

KW - EBV

KW - IDENTIFICATION

KW - HYPERMUTATION

KW - REPLICATION

U2 - 10.1016/j.virol.2006.01.015

DO - 10.1016/j.virol.2006.01.015

M3 - Journal article

VL - 350

SP - 164

EP - 170

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -