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The genome of Naegleria gruberi illuminates early eukaryotic versatility.

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The genome of Naegleria gruberi illuminates early eukaryotic versatility. / Fritz-Laylin, Lillian K.; Prochnik, Simon E.; Ginger, Michael L. et al.
In: Cell, Vol. 140, No. 5, 05.03.2010, p. 631-642.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Fritz-Laylin, LK, Prochnik, SE, Ginger, ML, Dacks, JB, Carpenter, ML, Field, MC, Kuo, A, Paredez, A, Chapman, J, Pham, J, Shu, S, Neupane, R, Cipriano, M, Mancuso, J, Tu, H, Salamov, A, Lindquist, E, Shapiro, H, Lucas, S, Grigoriev, IV, Cande, WZ, Fulton, C, Rokhsar, DS & Dawson, SC 2010, 'The genome of Naegleria gruberi illuminates early eukaryotic versatility.', Cell, vol. 140, no. 5, pp. 631-642. https://doi.org/10.1016/j.cell.2010.01.032

APA

Fritz-Laylin, L. K., Prochnik, S. E., Ginger, M. L., Dacks, J. B., Carpenter, M. L., Field, M. C., Kuo, A., Paredez, A., Chapman, J., Pham, J., Shu, S., Neupane, R., Cipriano, M., Mancuso, J., Tu, H., Salamov, A., Lindquist, E., Shapiro, H., Lucas, S., ... Dawson, S. C. (2010). The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell, 140(5), 631-642. https://doi.org/10.1016/j.cell.2010.01.032

Vancouver

Fritz-Laylin LK, Prochnik SE, Ginger ML, Dacks JB, Carpenter ML, Field MC et al. The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell. 2010 Mar 5;140(5):631-642. doi: 10.1016/j.cell.2010.01.032

Author

Fritz-Laylin, Lillian K. ; Prochnik, Simon E. ; Ginger, Michael L. et al. / The genome of Naegleria gruberi illuminates early eukaryotic versatility. In: Cell. 2010 ; Vol. 140, No. 5. pp. 631-642.

Bibtex

@article{885ad7e67bda421aacbab83fc9468e86,
title = "The genome of Naegleria gruberi illuminates early eukaryotic versatility.",
abstract = "Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic lineages over a billion years ago. Analysis of the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity for both aerobic respiration and anaerobic metabolism with concomitant hydrogen production, with fundamental implications for the evolution of organelle metabolism. The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukaryotic inventions. Moreover, we construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, reveals a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal, sexual, signaling, and metabolic modules.",
author = "Fritz-Laylin, {Lillian K.} and Prochnik, {Simon E.} and Ginger, {Michael L.} and Dacks, {Joel B.} and Carpenter, {Meredith L.} and Field, {Mark C.} and Alan Kuo and Alex Paredez and Jarrod Chapman and Jonathan Pham and Shengqiang Shu and Rochak Neupane and Michael Cipriano and Joel Mancuso and Hank Tu and Asaf Salamov and Erika Lindquist and Harris Shapiro and Susan Lucas and Grigoriev, {Igor V.} and Cande, {W. Z.} and C. Fulton and Rokhsar, {D. S.} and Dawson, {Scott C.}",
year = "2010",
month = mar,
day = "5",
doi = "10.1016/j.cell.2010.01.032",
language = "English",
volume = "140",
pages = "631--642",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - The genome of Naegleria gruberi illuminates early eukaryotic versatility.

AU - Fritz-Laylin, Lillian K.

AU - Prochnik, Simon E.

AU - Ginger, Michael L.

AU - Dacks, Joel B.

AU - Carpenter, Meredith L.

AU - Field, Mark C.

AU - Kuo, Alan

AU - Paredez, Alex

AU - Chapman, Jarrod

AU - Pham, Jonathan

AU - Shu, Shengqiang

AU - Neupane, Rochak

AU - Cipriano, Michael

AU - Mancuso, Joel

AU - Tu, Hank

AU - Salamov, Asaf

AU - Lindquist, Erika

AU - Shapiro, Harris

AU - Lucas, Susan

AU - Grigoriev, Igor V.

AU - Cande, W. Z.

AU - Fulton, C.

AU - Rokhsar, D. S.

AU - Dawson, Scott C.

PY - 2010/3/5

Y1 - 2010/3/5

N2 - Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic lineages over a billion years ago. Analysis of the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity for both aerobic respiration and anaerobic metabolism with concomitant hydrogen production, with fundamental implications for the evolution of organelle metabolism. The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukaryotic inventions. Moreover, we construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, reveals a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal, sexual, signaling, and metabolic modules.

AB - Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic lineages over a billion years ago. Analysis of the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity for both aerobic respiration and anaerobic metabolism with concomitant hydrogen production, with fundamental implications for the evolution of organelle metabolism. The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukaryotic inventions. Moreover, we construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, reveals a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal, sexual, signaling, and metabolic modules.

UR - http://www.scopus.com/inward/record.url?scp=77649290275&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2010.01.032

DO - 10.1016/j.cell.2010.01.032

M3 - Journal article

VL - 140

SP - 631

EP - 642

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -