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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The interferon response to intracellular DNA
T2 - why so many receptors?
AU - Unterholzner, Leonie
N1 - Copyright © 2013 Elsevier GmbH. All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.
AB - The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.
KW - Animals
KW - Autoimmunity
KW - DNA
KW - Gene Expression
KW - Humans
KW - Immunity, Innate
KW - Inflammation
KW - Interferon Type I
KW - Receptors, Cell Surface
KW - Virus Diseases
U2 - 10.1016/j.imbio.2013.07.007
DO - 10.1016/j.imbio.2013.07.007
M3 - Journal article
C2 - 23962476
VL - 218
SP - 1312
EP - 1321
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 11
ER -