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The isolation and amino acid composition of senile plaque core protein

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<mark>Journal publication date</mark>1983
<mark>Journal</mark>Experimental Brain Research
Issue number2
Volume259
Number of pages5
Pages (from-to)348-52
Publication statusPublished
Original languageEnglish

Abstract

A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.