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The multiple faces of proteinkinase R in antiviral defense

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The multiple faces of proteinkinase R in antiviral defense. / Munir, Muhammad; Berg, Mikael.

In: Virulence, Vol. 4, No. 1, 01.01.2013, p. 85-89.

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Munir, Muhammad ; Berg, Mikael. / The multiple faces of proteinkinase R in antiviral defense. In: Virulence. 2013 ; Vol. 4, No. 1. pp. 85-89.

Bibtex

@article{22f1e2f14f854b14a7329888e3ff8996,
title = "The multiple faces of proteinkinase R in antiviral defense",
abstract = "Various pattern recognition receptors (PRRs) have been implicated in the detection of viral RNA and subsequent interferon (IFN) gene expression, including the double-stranded RNA-dependent proteinkinase R (PKR). Now, a novel role of PKR has been unveiled, as it was shown that, upon the infection with certain viruses, PKR is crucial for the integrity of newly synthesized IFN mRNA, thereby generating an optimal host antiviral immune response. There is a need of future studies to investigate additional roles of PKR in innate immunity and the molecular understanding of this novel function of PKR.",
keywords = "Animals, Gene Expression Regulation, Humans, Interferons, Models, Biological, RNA Stability, Virus Diseases, eIF-2 Kinase, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Muhammad Munir and Mikael Berg",
year = "2013",
month = jan
day = "1",
doi = "10.4161/viru.23134",
language = "English",
volume = "4",
pages = "85--89",
journal = "Virulence",
issn = "2150-5594",
publisher = "Taylor and Francis",
number = "1",

}

RIS

TY - JOUR

T1 - The multiple faces of proteinkinase R in antiviral defense

AU - Munir, Muhammad

AU - Berg, Mikael

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Various pattern recognition receptors (PRRs) have been implicated in the detection of viral RNA and subsequent interferon (IFN) gene expression, including the double-stranded RNA-dependent proteinkinase R (PKR). Now, a novel role of PKR has been unveiled, as it was shown that, upon the infection with certain viruses, PKR is crucial for the integrity of newly synthesized IFN mRNA, thereby generating an optimal host antiviral immune response. There is a need of future studies to investigate additional roles of PKR in innate immunity and the molecular understanding of this novel function of PKR.

AB - Various pattern recognition receptors (PRRs) have been implicated in the detection of viral RNA and subsequent interferon (IFN) gene expression, including the double-stranded RNA-dependent proteinkinase R (PKR). Now, a novel role of PKR has been unveiled, as it was shown that, upon the infection with certain viruses, PKR is crucial for the integrity of newly synthesized IFN mRNA, thereby generating an optimal host antiviral immune response. There is a need of future studies to investigate additional roles of PKR in innate immunity and the molecular understanding of this novel function of PKR.

KW - Animals

KW - Gene Expression Regulation

KW - Humans

KW - Interferons

KW - Models, Biological

KW - RNA Stability

KW - Virus Diseases

KW - eIF-2 Kinase

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.4161/viru.23134

DO - 10.4161/viru.23134

M3 - Journal article

C2 - 23314571

VL - 4

SP - 85

EP - 89

JO - Virulence

JF - Virulence

SN - 2150-5594

IS - 1

ER -