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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

Research output: Contribution to journalJournal article

Published
  • Timothy R. Rudd
  • Mark A. Skidmore
  • Scott E. Guimond
  • Joseph Holman
  • Jeremy E. Turnbull
  • Robert M. Lauder
  • David G. Fernig
  • Edwin A. Yates
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<mark>Journal publication date</mark>11/2009
<mark>Journal</mark>Thrombosis and Haemostasis
Issue number5
Volume102
Number of pages5
Pages (from-to)874-878
Publication StatusPublished
<mark>Original language</mark>English
Event16th Heparin Symposium - Loveno, Italy
Duration: 1/01/2008 → …

Conference

Conference16th Heparin Symposium
CountryItaly
CityLoveno
Period1/01/08 → …

Abstract

The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.