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The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Research output: Contribution to journalJournal article

Published

Journal publication date08/2005
JournalBiochemical Society Transactions
Journal number4
Volume33
Number of pages3
Pages548-550
Original languageEnglish

Abstract

By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.