Home > Research > Publications & Outputs > The production of hydrogen peroxide during earl...

Research

Links

Keywords

View graph of relations

The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? / Tabner, Brian; Turnbull, Stuart; Fullwood, N J et al.
In: Biochemical Society Transactions, Vol. 33, No. 4, 08.2005, p. 548-550.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Tabner, B, Turnbull, S, Fullwood, NJ, German, M & Allsop, D 2005, 'The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?', Biochemical Society Transactions, vol. 33, no. 4, pp. 548-550. <http://www.biochemsoctrans.org/bst/033/bst0330548.htm>

APA

Tabner, B., Turnbull, S., Fullwood, N. J., German, M., & Allsop, D. (2005). The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions, 33(4), 548-550. http://www.biochemsoctrans.org/bst/033/bst0330548.htm

Vancouver

Tabner B, Turnbull S, Fullwood NJ, German M, Allsop D. The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions. 2005 Aug;33(4):548-550.

Author

Tabner, Brian ; Turnbull, Stuart ; Fullwood, N J et al. / The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?. In: Biochemical Society Transactions. 2005 ; Vol. 33, No. 4. pp. 548-550.

Bibtex

@article{773e010e1103486bb45eac3a61ed5129,
title = "The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?",
abstract = "By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.",
keywords = "Alzheimer's disease, H2O2, neuradegeneration, Parkinson's disease, prion, protein aggregation, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, ALPHA-SYNUCLEIN, A-BETA, PEPTIDE, GENERATION, OLIGOMERS, RADICALS",
author = "Brian Tabner and Stuart Turnbull and Fullwood, {N J} and Matthew German and D Allsop",
year = "2005",
month = aug,
language = "English",
volume = "33",
pages = "548--550",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

AU - Tabner, Brian

AU - Turnbull, Stuart

AU - Fullwood, N J

AU - German, Matthew

AU - Allsop, D

PY - 2005/8

Y1 - 2005/8

N2 - By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.

AB - By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.

KW - Alzheimer's disease

KW - H2O2

KW - neuradegeneration

KW - Parkinson's disease

KW - prion

KW - protein aggregation

KW - PARKINSONS-DISEASE

KW - ALZHEIMERS-DISEASE

KW - ALPHA-SYNUCLEIN

KW - A-BETA

KW - PEPTIDE

KW - GENERATION

KW - OLIGOMERS

KW - RADICALS

M3 - Journal article

VL - 33

SP - 548

EP - 550

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 4

ER -