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The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia.

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The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. / Hutton, Samuel B.; Huddy, Vyv; Barnes, Thomas R. E. et al.
In: Biological Psychiatry, Vol. 56, No. 8, 15.10.2004, p. 553-559.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Hutton, SB, Huddy, V, Barnes, TRE, Robbins, TW, Crawford, TJ, Kennard, C & Joyce, EM 2004, 'The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia.', Biological Psychiatry, vol. 56, no. 8, pp. 553-559. https://doi.org/10.1016/j.biopsych.2004.07.002

APA

Hutton, S. B., Huddy, V., Barnes, T. R. E., Robbins, T. W., Crawford, T. J., Kennard, C., & Joyce, E. M. (2004). The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry, 56(8), 553-559. https://doi.org/10.1016/j.biopsych.2004.07.002

Vancouver

Hutton SB, Huddy V, Barnes TRE, Robbins TW, Crawford TJ, Kennard C et al. The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry. 2004 Oct 15;56(8):553-559. doi: 10.1016/j.biopsych.2004.07.002

Author

Hutton, Samuel B. ; Huddy, Vyv ; Barnes, Thomas R. E. et al. / The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. In: Biological Psychiatry. 2004 ; Vol. 56, No. 8. pp. 553-559.

Bibtex

@article{4a76fb1c25084154bc8d23d1b8a4a868,
title = "The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia.",
abstract = "Background Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced inconsistent findings. Methods We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first-episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis. Results Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated psychosis. Conclusions These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.",
keywords = "Antisaccade, executive function, oculomotor, schizophrenia, smooth pursuit, working memory",
author = "Hutton, {Samuel B.} and Vyv Huddy and Barnes, {Thomas R. E.} and Robbins, {Trevor W.} and Crawford, {Trevor J.} and Christopher Kennard and Joyce, {Eileen M.}",
year = "2004",
month = oct,
day = "15",
doi = "10.1016/j.biopsych.2004.07.002",
language = "English",
volume = "56",
pages = "553--559",
journal = "Biological Psychiatry",
issn = "1873-2402",
publisher = "Elsevier USA",
number = "8",

}

RIS

TY - JOUR

T1 - The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia.

AU - Hutton, Samuel B.

AU - Huddy, Vyv

AU - Barnes, Thomas R. E.

AU - Robbins, Trevor W.

AU - Crawford, Trevor J.

AU - Kennard, Christopher

AU - Joyce, Eileen M.

PY - 2004/10/15

Y1 - 2004/10/15

N2 - Background Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced inconsistent findings. Methods We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first-episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis. Results Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated psychosis. Conclusions These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.

AB - Background Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced inconsistent findings. Methods We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first-episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis. Results Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated psychosis. Conclusions These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.

KW - Antisaccade

KW - executive function

KW - oculomotor

KW - schizophrenia

KW - smooth pursuit

KW - working memory

U2 - 10.1016/j.biopsych.2004.07.002

DO - 10.1016/j.biopsych.2004.07.002

M3 - Journal article

VL - 56

SP - 553

EP - 559

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 1873-2402

IS - 8

ER -