The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

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The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. / Yilmaz, Zeynep; Kaplan, Allan S.; Tiwari, Arun K. et al.
In: Journal of Psychiatric Research, Vol. 55, 08.2014, p. 77-86.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Yilmaz, Z, Kaplan, AS, Tiwari, AK, Levitan, RD, Piran, S, Bergen, AW, Kaye, WH, Hakonarson, H, Wang, K, Berrettini, WH, Brandt, HA, Bulik, CM, Crawford, S, Crow, S, Fichter, MM, Halmi, KA, Johnson, CL, Keel, PK, Klump, KL, Magistretti, P, Mitchell, J, Strober, M, Thornton, LM, Treasure, J, Woodside, DB, Knight, J & Kennedy, JL 2014, 'The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa', Journal of Psychiatric Research, vol. 55, pp. 77-86. https://doi.org/10.1016/j.jpsychires.2014.04.005

APA

Yilmaz, Z., Kaplan, A. S., Tiwari, A. K., Levitan, R. D., Piran, S., Bergen, A. W., Kaye, W. H., Hakonarson, H., Wang, K., Berrettini, W. H., Brandt, H. A., Bulik, C. M., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C. L., Keel, P. K., Klump, K. L., ... Kennedy, J. L. (2014). The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. Journal of Psychiatric Research, 55, 77-86. https://doi.org/10.1016/j.jpsychires.2014.04.005

Vancouver

Yilmaz Z, Kaplan AS, Tiwari AK, Levitan RD, Piran S, Bergen AW et al. The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. Journal of Psychiatric Research. 2014 Aug;55:77-86. Epub 2014 Apr 16. doi: 10.1016/j.jpsychires.2014.04.005

Author

Yilmaz, Zeynep ; Kaplan, Allan S. ; Tiwari, Arun K. et al. / The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. In: Journal of Psychiatric Research. 2014 ; Vol. 55. pp. 77-86.

Bibtex

@article{f3db8764dd7a46419ce37b9d1a97b858,

title = "The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa",

abstract = "OBJECTIVE: Although low weight is a key factor contributing to the high mortality in anorexia nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia nervosa (BN) patients with similar psychopathology. Studies of genes involved in appetite and weight regulation in eating disorders have yielded variable findings, in part due to small sample size and clinical heterogeneity. This study: (1) assessed the role of leptin, melanocortin, and neurotrophin genetic variants in conferring risk for AN and BN; and (2) explored the involvement of these genes in body mass index (BMI) variations within AN and BN.METHOD: Our sample consisted of 745 individuals with AN without a history of BN, 245 individuals with BN without a history of AN, and 321 controls. We genotyped 20 markers with known or putative function among genes selected from leptin, melanocortin, and neurotrophin systems.RESULTS: There were no significant differences in allele frequencies among individuals with AN, BN, and controls. AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).DISCUSSION: To our knowledge, this is the first study to address the issue of clinical heterogeneity in eating disorder genetic research and to explore the role of known or putatively functional markers in genes regulating appetite and weight in individuals with AN and BN. If replicated, our results may serve as an important first step toward gaining a better understanding of weight regulation in eating disorders.",

keywords = "Adult, Agouti-Related Protein, Anorexia Nervosa, Body Mass Index, Body Weight, Bulimia Nervosa, Case-Control Studies, Female, Genotyping Techniques, Humans, Leptin, Melanocortins, Membrane Glycoproteins, Middle Aged, Nerve Growth Factors, Polymorphism, Single Nucleotide, Protein Kinases, Protein-Tyrosine Kinases",

author = "Zeynep Yilmaz and Kaplan, {Allan S.} and Tiwari, {Arun K.} and Levitan, {Robert D.} and Sara Piran and Bergen, {Andrew W.} and Kaye, {Walter H.} and Hakon Hakonarson and Kai Wang and Berrettini, {Wade H.} and Brandt, {Harry A.} and Bulik, {Cynthia M.} and Steven Crawford and Scott Crow and Fichter, {Manfred M.} and Halmi, {Katherine A.} and Johnson, {Craig L.} and Keel, {Pamela K.} and Klump, {Kelly L.} and Pierre Magistretti and James Mitchell and Michael Strober and Thornton, {Laura M.} and Janet Treasure and Woodside, {D. Blake} and Joanne Knight and Kennedy, {James L.}",

year = "2014",

month = aug,

doi = "10.1016/j.jpsychires.2014.04.005",

language = "English",

volume = "55",

pages = "77--86",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

AU - Yilmaz, Zeynep

AU - Kaplan, Allan S.

AU - Tiwari, Arun K.

AU - Levitan, Robert D.

AU - Piran, Sara

AU - Bergen, Andrew W.

AU - Kaye, Walter H.

AU - Hakonarson, Hakon

AU - Wang, Kai

AU - Berrettini, Wade H.

AU - Brandt, Harry A.

AU - Bulik, Cynthia M.

AU - Crawford, Steven

AU - Crow, Scott

AU - Fichter, Manfred M.

AU - Halmi, Katherine A.

AU - Johnson, Craig L.

AU - Keel, Pamela K.

AU - Klump, Kelly L.

AU - Magistretti, Pierre

AU - Mitchell, James

AU - Strober, Michael

AU - Thornton, Laura M.

AU - Treasure, Janet

AU - Woodside, D. Blake

AU - Knight, Joanne

AU - Kennedy, James L.

PY - 2014/8

Y1 - 2014/8

N2 - OBJECTIVE: Although low weight is a key factor contributing to the high mortality in anorexia nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia nervosa (BN) patients with similar psychopathology. Studies of genes involved in appetite and weight regulation in eating disorders have yielded variable findings, in part due to small sample size and clinical heterogeneity. This study: (1) assessed the role of leptin, melanocortin, and neurotrophin genetic variants in conferring risk for AN and BN; and (2) explored the involvement of these genes in body mass index (BMI) variations within AN and BN.METHOD: Our sample consisted of 745 individuals with AN without a history of BN, 245 individuals with BN without a history of AN, and 321 controls. We genotyped 20 markers with known or putative function among genes selected from leptin, melanocortin, and neurotrophin systems.RESULTS: There were no significant differences in allele frequencies among individuals with AN, BN, and controls. AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).DISCUSSION: To our knowledge, this is the first study to address the issue of clinical heterogeneity in eating disorder genetic research and to explore the role of known or putatively functional markers in genes regulating appetite and weight in individuals with AN and BN. If replicated, our results may serve as an important first step toward gaining a better understanding of weight regulation in eating disorders.

AB - OBJECTIVE: Although low weight is a key factor contributing to the high mortality in anorexia nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia nervosa (BN) patients with similar psychopathology. Studies of genes involved in appetite and weight regulation in eating disorders have yielded variable findings, in part due to small sample size and clinical heterogeneity. This study: (1) assessed the role of leptin, melanocortin, and neurotrophin genetic variants in conferring risk for AN and BN; and (2) explored the involvement of these genes in body mass index (BMI) variations within AN and BN.METHOD: Our sample consisted of 745 individuals with AN without a history of BN, 245 individuals with BN without a history of AN, and 321 controls. We genotyped 20 markers with known or putative function among genes selected from leptin, melanocortin, and neurotrophin systems.RESULTS: There were no significant differences in allele frequencies among individuals with AN, BN, and controls. AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).DISCUSSION: To our knowledge, this is the first study to address the issue of clinical heterogeneity in eating disorder genetic research and to explore the role of known or putatively functional markers in genes regulating appetite and weight in individuals with AN and BN. If replicated, our results may serve as an important first step toward gaining a better understanding of weight regulation in eating disorders.

KW - Adult

KW - Agouti-Related Protein

KW - Anorexia Nervosa

KW - Body Mass Index

KW - Body Weight

KW - Bulimia Nervosa

KW - Case-Control Studies

KW - Female

KW - Genotyping Techniques

KW - Humans

KW - Leptin

KW - Melanocortins

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Nerve Growth Factors

KW - Polymorphism, Single Nucleotide

KW - Protein Kinases

KW - Protein-Tyrosine Kinases

U2 - 10.1016/j.jpsychires.2014.04.005

DO - 10.1016/j.jpsychires.2014.04.005

M3 - Journal article

C2 - 24831852

VL - 55

SP - 77

EP - 86

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

ER -

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