The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet

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The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet. / Ghimire, B.; Szili, E.J.; Lamichhane, P. et al.
In: Applied Physics Letters, Vol. 114, No. 9, 093701, 04.03.2019.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ghimire, B , Szili, EJ, Lamichhane, P, Short, RD, Lim, JS, Attri, P, Masur, K, Weltmann, K-D, Hong, S-H & Choi, EH 2019, 'The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet', Applied Physics Letters, vol. 114, no. 9, 093701. https://doi.org/10.1063/1.5086522

APA

Ghimire, B., Szili, E. J., Lamichhane, P., Short, R. D., Lim, J. S., Attri, P., Masur, K., Weltmann, K-D., Hong, S-H., & Choi, E. H. (2019). The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet. Applied Physics Letters, 114(9), Article 093701. https://doi.org/10.1063/1.5086522

Vancouver

Ghimire B , Szili EJ, Lamichhane P, Short RD, Lim JS, Attri P et al. The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet. Applied Physics Letters. 2019 Mar 4;114(9):093701. doi: 10.1063/1.5086522

Author

Ghimire, B. ; Szili, E.J. ; Lamichhane, P. et al. / The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet. In: Applied Physics Letters. 2019 ; Vol. 114, No. 9.

Bibtex

@article{fcc39d312f3141b88dcdebbaf15aeec7,

title = "The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet",

abstract = "Cold atmospheric pressure plasma jets (plasma) operated in ambient air provide a rich source of reactive oxygen and nitrogen species (RONS), which are known to influence biological processes important in disease. In the plasma treatment of diseased tissue such as subcutaneous cancer tumors, plasma RONS need to first traverse an interface between the plasma-skin surface and second be transported to millimeter depths in order to reach deep-seated diseased cells. However, the mechanisms in the plasma generation of RONS within soft tissues are not understood. In this study, we track the plasma jet delivery of RONS into a tissue model target and we delineate two processes: through target delivery of RONS generated (primarily) in the plasma jet and in situ RONS generation by UV photolysis within the target. We demonstrate that UV photolysis promotes the rapid generation of RONS in the tissue model target's surface after which the RONS are transported to millimeter depths via a slower molecular process. Our results imply that the flux of UV photons from plasma jets is important for delivering RONS through seemingly impenetrable barriers such as skin. The findings have implications not only in treatments of living tissues but also in the functionalization of soft hydrated biomaterials such as hydrogels and extracellular matrix derived tissue scaffolds.",

keywords = "Atmospheric movements, Atmospheric pressure, Histology, Nitrogen plasma, Photolysis, Plasma applications, Plasma jets, Scaffolds (biology), Atmospheric pressure plasma jets, Biological process, Extracellular matrices, Functionalizations, Molecular transport, Plasma generation, Rapid generations, Reactive oxygen and nitrogen species, Tissue",

author = "B. Ghimire and E.J. Szili and P. Lamichhane and R.D. Short and J.S. Lim and P. Attri and K. Masur and K.-D. Weltmann and S.-H. Hong and E.H. Choi",

year = "2019",

month = mar,

day = "4",

doi = "10.1063/1.5086522",

language = "English",

volume = "114",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics Inc.",

number = "9",

}

RIS

TY - JOUR

T1 - The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet

AU - Ghimire, B.

AU - Szili, E.J.

AU - Lamichhane, P.

AU - Short, R.D.

AU - Lim, J.S.

AU - Attri, P.

AU - Masur, K.

AU - Weltmann, K.-D.

AU - Hong, S.-H.

AU - Choi, E.H.

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Cold atmospheric pressure plasma jets (plasma) operated in ambient air provide a rich source of reactive oxygen and nitrogen species (RONS), which are known to influence biological processes important in disease. In the plasma treatment of diseased tissue such as subcutaneous cancer tumors, plasma RONS need to first traverse an interface between the plasma-skin surface and second be transported to millimeter depths in order to reach deep-seated diseased cells. However, the mechanisms in the plasma generation of RONS within soft tissues are not understood. In this study, we track the plasma jet delivery of RONS into a tissue model target and we delineate two processes: through target delivery of RONS generated (primarily) in the plasma jet and in situ RONS generation by UV photolysis within the target. We demonstrate that UV photolysis promotes the rapid generation of RONS in the tissue model target's surface after which the RONS are transported to millimeter depths via a slower molecular process. Our results imply that the flux of UV photons from plasma jets is important for delivering RONS through seemingly impenetrable barriers such as skin. The findings have implications not only in treatments of living tissues but also in the functionalization of soft hydrated biomaterials such as hydrogels and extracellular matrix derived tissue scaffolds.

AB - Cold atmospheric pressure plasma jets (plasma) operated in ambient air provide a rich source of reactive oxygen and nitrogen species (RONS), which are known to influence biological processes important in disease. In the plasma treatment of diseased tissue such as subcutaneous cancer tumors, plasma RONS need to first traverse an interface between the plasma-skin surface and second be transported to millimeter depths in order to reach deep-seated diseased cells. However, the mechanisms in the plasma generation of RONS within soft tissues are not understood. In this study, we track the plasma jet delivery of RONS into a tissue model target and we delineate two processes: through target delivery of RONS generated (primarily) in the plasma jet and in situ RONS generation by UV photolysis within the target. We demonstrate that UV photolysis promotes the rapid generation of RONS in the tissue model target's surface after which the RONS are transported to millimeter depths via a slower molecular process. Our results imply that the flux of UV photons from plasma jets is important for delivering RONS through seemingly impenetrable barriers such as skin. The findings have implications not only in treatments of living tissues but also in the functionalization of soft hydrated biomaterials such as hydrogels and extracellular matrix derived tissue scaffolds.

KW - Atmospheric movements

KW - Atmospheric pressure

KW - Histology

KW - Nitrogen plasma

KW - Photolysis

KW - Plasma applications

KW - Plasma jets

KW - Scaffolds (biology)

KW - Atmospheric pressure plasma jets

KW - Biological process

KW - Extracellular matrices

KW - Functionalizations

KW - Molecular transport

KW - Plasma generation

KW - Rapid generations

KW - Reactive oxygen and nitrogen species

KW - Tissue

U2 - 10.1063/1.5086522

DO - 10.1063/1.5086522

M3 - Journal article

VL - 114

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

IS - 9

M1 - 093701

ER -

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