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The role of working memory and attentional disengagement in Inhibitory control: effects of aging and Alzheimer's disease

Research output: Contribution to journalJournal article


Journal publication date10/2013
Number of pages14
Early online date21/08/12
Original languageEnglish


Background: Patients with Alzheimer's disease have an impairment of inhibitory control for reasons that are currently unclear. Using an eye-tracking task (the gap-overlap paradigm) we examined whether the uncorrected errors relate to the task of attentional disengagement in preparation for action. Alternatively the difficulty in correcting for errors may be caused by the working memory representation of the task. A major aim of this study was to distinguish between the effects of healthy aging and neurodegenerative disease on the voluntary control of saccadic eye movements.

Methods: Using the antisaccade task (AST) and prosaccade task (PST) with the 'gap' and 'overlap' procedures we obtained detailed eye-tracking measures in patients with eighteen patients with probable Alzheimer's disease, twenty-five patients with Parkinson's disease and seventeen healthy young and eighteen old participants.

Results: Uncorrected errors in the AST were selectively increased in Alzheimer's disease, but not in Parkinson's disease compared to the control groups. These
uncorrected errors were strongly correlated with spatial working memory. There was an increase in the saccade reaction times to targets that were presented simultaneously with the fixation stimulus, compared to the removal of fixation. This 'gap' effect (i.e. overlap - gap) saccade reaction time was elevated in the older groups compared to young group, which yielded a strong effect of aging and no specific effect of neurodegenerative disease. Healthy aging, rather than neurodegenerative disease accounted for the increase in the saccade reaction times to the target that are presented simultaneously with a fixation stimulus.

Conclusions: These results suggest that the impairment of inhibitory control in the AST may provide a convenient and putative mark of working memory dysfunction in Alzheimer's disease.