Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The sequential analysis of repeated binary responses: a score test for the case of three time points.
AU - Sooriyarachchi, Marina Roshini
AU - Whitehead, John
AU - Whitehead, Anne
AU - Bolland, Kim
N1 - RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research
PY - 2006/7/15
Y1 - 2006/7/15
N2 - In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.
AB - In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.
KW - binary data • longitudinal data • repeated observations • score test • sequential clinical trial
U2 - 10.1002/sim.2339
DO - 10.1002/sim.2339
M3 - Journal article
VL - 25
SP - 2196
EP - 2214
JO - Statistics in Medicine
JF - Statistics in Medicine
SN - 1097-0258
IS - 13
ER -