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The sequential analysis of repeated binary responses: a score test for the case of three time points.

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The sequential analysis of repeated binary responses: a score test for the case of three time points. / Sooriyarachchi, Marina Roshini; Whitehead, John; Whitehead, Anne et al.
In: Statistics in Medicine, Vol. 25, No. 13, 15.07.2006, p. 2196-2214.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Sooriyarachchi MR, Whitehead J, Whitehead A, Bolland K. The sequential analysis of repeated binary responses: a score test for the case of three time points. Statistics in Medicine. 2006 Jul 15;25(13):2196-2214. doi: 10.1002/sim.2339

Author

Sooriyarachchi, Marina Roshini ; Whitehead, John ; Whitehead, Anne et al. / The sequential analysis of repeated binary responses: a score test for the case of three time points. In: Statistics in Medicine. 2006 ; Vol. 25, No. 13. pp. 2196-2214.

Bibtex

@article{56cc3105102b490aab6e32fd36a694eb,
title = "The sequential analysis of repeated binary responses: a score test for the case of three time points.",
abstract = "In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright {\textcopyright} 2005 John Wiley & Sons, Ltd.",
keywords = "binary data • longitudinal data • repeated observations • score test • sequential clinical trial",
author = "Sooriyarachchi, {Marina Roshini} and John Whitehead and Anne Whitehead and Kim Bolland",
note = "RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research",
year = "2006",
month = jul,
day = "15",
doi = "10.1002/sim.2339",
language = "English",
volume = "25",
pages = "2196--2214",
journal = "Statistics in Medicine",
issn = "1097-0258",
publisher = "John Wiley and Sons Ltd",
number = "13",

}

RIS

TY - JOUR

T1 - The sequential analysis of repeated binary responses: a score test for the case of three time points.

AU - Sooriyarachchi, Marina Roshini

AU - Whitehead, John

AU - Whitehead, Anne

AU - Bolland, Kim

N1 - RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research

PY - 2006/7/15

Y1 - 2006/7/15

N2 - In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.

AB - In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.

KW - binary data • longitudinal data • repeated observations • score test • sequential clinical trial

U2 - 10.1002/sim.2339

DO - 10.1002/sim.2339

M3 - Journal article

VL - 25

SP - 2196

EP - 2214

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 1097-0258

IS - 13

ER -